Modulation of Spinal Cord LTP by Kappa Opioids

Terman, Gregory W.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Drug Abuse (NIDA)
• Type: Research Project (R01)
• Project #: 5R01DA014588-02
• Application #: 6711041
• Study Section: Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
• Program Officer: Thomas, David A
• Project Start: 2003-03-01
• Project End: 2006-01-31
• Budget Start: 2004-02-01
• Budget End: 2005-01-31
• Support Year: 2
• Fiscal Year: 2004
• Total Cost: $265,300

Institution

• Name: University of Washington
• Department: Anesthesiology
• Type: Schools of Medicine
• DUNS #: 605799469
• City: Seattle
• State: WA
• Country: United States
• Zip Code: 98195

Publications

Thomson, Lisa M; Terman, Gregory W; Zeng, Jinsong et al. (2008) Decreased substance P and NK1 receptor immunoreactivity and function in the spinal cord dorsal horn of morphine-treated neonatal rats. J Pain 9:11-9

Zeng, Jinsong; Thomson, Lisa M; Aicher, Sue A et al. (2006) Primary afferent NMDA receptors increase dorsal horn excitation and mediate opiate tolerance in neonatal rats. J Neurosci 26:12033-42

Thomson, Lisa M; Zeng, Jinsong; Terman, Gregory W (2006) Differential effect of glutamate transporter inhibition on EPSCs in the morphine naive and morphine tolerant neonatal spinal cord slice. Neurosci Lett 407:64-9

Thomson, L M; Zeng, J; Terman, G W (2006) An N-methyl-D-aspartate receptor mediated large, low-frequency, spontaneous excitatory postsynaptic current in neonatal rat spinal dorsal horn neurons. Neuroscience 141:1489-501

Terman, Gregory W; Jin, Wenzhen; Cheong, Young-Pyo et al. (2004) G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. Br J Pharmacol 141:55-64