The rapidly escalating abuse of methamphetamine (METH) in the United States, places a sense of urgency on understanding the consequences of METH use during pregnancy for the developing child. To our knowledge, IDEAL (Infant Development Environment and Lifestyle) is the only prospective longitudinal NIH study of prenatal Methamphetamine exposure and child outcome. This is a competitive renewal application for the 4-7 year follow-up of the IDEAL cohort. The IDEAL data collection sites are from diverse populations in Iowa, Oklahoma, California, and Hawaii where METH use by pregnant women is prevalent. We have followed 204 Methamphetamine exposed and 208 Comparison children since birth who are now completing assessments at 24 and 30 months. Here, we propose a 4-7 year follow-up, an important age range when executive function neural networks develop and children make the critical transition to school. Our plan is to study a relatively narrow band of executive function domains outcomes supported by the published preclinical and clinical literature and our own preliminary findings. We also plan to study how these executive function domains affect school related academic skills. Our preliminary findings show effects of prenatal Methamphetamine exposure on fetal growth, and on behavior between birth and 3 years on arousal-regulation, attention, inhibitory control, motivation and motor control with some effects due to heavy Methamphetamine exposure. These effects suggest that motor development and precursors of executive function may be affected by prenatal Methamphetamine exposure. We also found effects of psychosocial risk factors including low SES, family conflict, maternal psychiatric status and abuse potential, and out of home placement. In this application, we plan to study the effects of prenatal Methamphetamine exposure on emerging executive function domains including higher order motivation, attention, memory, inhibitory control, visual motor integration, and motor control, and how the effects of prenatal Methamphetamine exposure are affected by psychosocial risk factors and by postnatal passive drug exposure (e.g. smoke).

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA014948-10
Application #
7842676
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Boyce, Cheryl A
Project Start
2001-09-25
Project End
2012-11-30
Budget Start
2010-06-01
Budget End
2011-11-30
Support Year
10
Fiscal Year
2010
Total Cost
$1,473,855
Indirect Cost
Name
Women and Infants Hospital-Rhode Island
Department
Type
DUNS #
069851913
City
Providence
State
RI
Country
United States
Zip Code
02905
Chakraborty, Arijit; Anstice, Nicola S; Jacobs, Robert J et al. (2017) Global motion perception is related to motor function in 4.5-year-old children born at risk of abnormal development. Vision Res 135:16-25
Eze, Nwando; Smith, Lynne M; LaGasse, Linda L et al. (2016) School-Aged Outcomes following Prenatal Methamphetamine Exposure: 7.5-Year Follow-Up from the Infant Development, Environment, and Lifestyle Study. J Pediatr 170:34-8.e1
Smith, Lynne M; Diaz, Sabrina; LaGasse, Linda L et al. (2015) Developmental and behavioral consequences of prenatal methamphetamine exposure: A review of the Infant Development, Environment, and Lifestyle (IDEAL) study. Neurotoxicol Teratol 51:35-44
Chakraborty, Arijit; Anstice, Nicola S; Jacobs, Robert J et al. (2015) Global motion perception is independent from contrast sensitivity for coherent motion direction discrimination and visual acuity in 4.5-year-old children. Vision Res 115:83-91
Chakraborty, Arijit; Anstice, Nicola S; Jacobs, Robert J et al. (2015) Prenatal exposure to recreational drugs affects global motion perception in preschool children. Sci Rep 5:16921
Wouldes, Trecia A; Lagasse, Linda L; Huestis, Marilyn A et al. (2014) Prenatal methamphetamine exposure and neurodevelopmental outcomes in children from 1 to 3 years. Neurotoxicol Teratol 42:77-84
Diaz, Sabrina D; Smith, Lynne M; LaGasse, Linda L et al. (2014) Effects of prenatal methamphetamine exposure on behavioral and cognitive findings at 7.5 years of age. J Pediatr 164:1333-8
Himes, Sarah K; LaGasse, Linda L; Derauf, Chris et al. (2014) Risk of neurobehavioral disinhibition in prenatal methamphetamine-exposed young children with positive hair toxicology results. Ther Drug Monit 36:535-43
Kiblawi, Zeina N; Smith, Lynne M; Diaz, Sabrina D et al. (2014) Prenatal methamphetamine exposure and neonatal and infant neurobehavioral outcome: results from the IDEAL study. Subst Abus 35:68-73
Kirlic, Namik; Newman, Elana; Lagasse, Linda L et al. (2013) Cortisol reactivity in two-year-old children prenatally exposed to methamphetamine. J Stud Alcohol Drugs 74:447-51

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