Consistent with PA-08-217, """"""""Drug Abuse Prevention Intervention Research"""""""", we propose to study neurobiological mechanisms that underlie currently recognized commonalities in behavioral manifestations of attention deficit hyperactivity disorder (ADHD) and drug addiction. Alterations in cortical dopamine systems may play a prominent role in ADHD, and that the beneficial effects of stimulant therapies (e.g. methylphenidate (MPH), amphetamines) lies in their ability to reduce abnormalities in prefrontal dopamine function. In this competitive renewal, we would like to continue our work on the relationship between stimulant therapy in juvenile rats and later drug-seeking behavior. Here, we will build upon our findings to: 1) directly confirm our preliminary observations regarding untoward later consequences of abnormalities in juvenile cortical dopamine function;2) continue to explore gender-related differences in the effects of early stimulant treatment;and 3) further define dopaminergic consequences of stimulant exposure during the juvenile period that may underlie later behavioral attributes of addiction. We will use behavioral, neurochemical, and neuroanatomical approaches to investigate prefrontal dopamine function and the emergence of substance abuse-related problems. Most importantly, we will use this information to develop new, preventative strategies that may be used to reduce drug abuse in this high-risk population.
We propose to study neurobiological mechanisms that underlie currently recognized commonalities in behavioral manifestations of attention deficit hyperactivity disorder (ADHD) and drug addiction. We will use behavioral, neurochemical, and neuroanatomical approaches to investigate prefrontal dopamine function and the emergence of substance abuse-related problems with the goal of developing new, preventative strategies that may be used to reduce drug abuse in this high-risk population.
|Lukkes, Jodi L; Meda, Shirisha; Norman, Kevin J et al. (2018) Anhedonic behavior and ?-amino butyric acid during a sensitive period in female rats exposed to early adversity. J Psychiatr Res 100:8-15|
|Lukkes, Jodi L; Meda, Shirisha; Thompson, Britta S et al. (2017) Early life stress and later peer distress on depressive behavior in adolescent female rats: Effects of a novel intervention on GABA and D2 receptors. Behav Brain Res 330:37-45|
|Jordan, Chloe J; Andersen, Susan L (2017) Sensitive periods of substance abuse: Early risk for the transition to dependence. Dev Cogn Neurosci 25:29-44|
|Lukkes, Jodi L; Freund, Nadja; Thompson, Britta S et al. (2016) Preventative treatment in an animal model of ADHD: Behavioral and biochemical effects of methylphenidate and its interactions with ovarian hormones in female rats. Eur Neuropsychopharmacol 26:1496-1506|
|Freund, Nadja; Thompson, Britta S; Sonntag, Kai et al. (2016) When the party is over: depressive-like states in rats following termination of cortical D1 receptor overexpression. Psychopharmacology (Berl) 233:1191-201|
|Andersen, Susan L (2016) Commentary on the special issue on the adolescent brain: Adolescence, trajectories, and the importance of prevention. Neurosci Biobehav Rev 70:329-333|
|Lukkes, Jodi L; Thompson, Britta S; Freund, Nadja et al. (2016) The developmental inter-relationships between activity, novelty preferences, and delay discounting in male and female rats. Dev Psychobiol 58:231-42|
|Schrantee, Anouk; Tamminga, Hyke G H; Bouziane, Cheima et al. (2016) Age-Dependent Effects of Methylphenidate on the Human Dopaminergic System in Young vs Adult Patients With Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial. JAMA Psychiatry 73:955-62|
|Andersen, Susan L (2015) Exposure to early adversity: Points of cross-species translation that can lead to improved understanding of depression. Dev Psychopathol 27:477-91|
|Brenhouse, Heather C; Thompson, Britta S; Sonntag, Kai C et al. (2015) Extinction and reinstatement to cocaine-associated cues in male and female juvenile rats and the role of D1 dopamine receptor. Neuropharmacology 95:22-8|
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