Three Generational Study We proposes to study intergenerational transmission of alcohol, tobacco, and other drug use (ATOD) across three generations (G1, G2, and G3). We will use children in the Three Generational Study (3GS), a community sample consisting of up to two of the biological children (G3) of at-risk early adult men (G2) in the Oregon Youth Study (OYS). Multiple indicators of ATOD in G3 will be assessed, including age of onset of use and growth in use over early to midadolescence. A dynamic developmental systems approach focusing on both general pathway psychopathology and outcome-specific risk factors will be used to examine the developmental pathways of precursors (e.g., ATOD awareness) and of the emergence of these behaviors from early childhood to adolescence. Hypotheses regarding cross-generational congruence in the onset and growth of ATOD also will be examined, as well as the transmission of contextual risk and problematic behaviors across three generations, and parenting behaviors and peer influences across two generations. Additionally, the role of ATOD in the etiology of three public health problems;namely health-risking sexual behavior, suicidal thoughts and behaviors, and dating violence will be tested. The OYS men show high levels of antisocial behavior (at age 25 years, 42% had two or more arrests) and substance use (estimated 50% lifetime diagnoses for alcohol dependence or abuse and 50% prevalence of marijuana use in the mid 20s). The men are currently ages 36-38 years and, with their parents (G1), have been involved in the OYS since the G2 men were ages 9-10 years.
Specific Aims will be addressed through the collection and analysis of data that will expand the sample size for the early time points (ages 3 to 11 years) and extend the study to ages 19-20 years. Additionally, we will undertake secondary data analysis of the OYS, OYS-Couples Study, and 3GS extant data sets from the beginning of the proposed study period.

Public Health Relevance

This study will use prospective data across three generations to examine social mechanisms involved in the familial transmission of substance use and three related public health problems;namely health-risking sexual behavior, suicidal thoughts and behaviors, and dating violence. The study will examine the roles of general risk pathways (e.g., parent antisocial behavior and deviant peer association) as well as outcome-specific risk factors and processes (e.g., parental substance use) in the etiology of alcohol, tobacco, and other drug use. Developmental similarities or congruence across generations in the age of onset, course, and severity of substance use (e.g., age of onset, escalation) will be a particular focus of study.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Special Emphasis Panel (ZRG1-RPIA-N (09))
Program Officer
Etz, Kathleen
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Oregon Social Learning Center, Inc.
United States
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Washburn, Isaac J; Capaldi, Deborah M (2015) Heterogeneity in men's marijuana use in the 20s: adolescent antecedents and consequences in the 30s. Dev Psychopathol 27:279-91
Tiberio, Stacey S; Kerr, David C R; Capaldi, Deborah M et al. (2014) Parental monitoring of children's media consumption: the long-term influences on body mass index in children. JAMA Pediatr 168:414-21
Capaldi, Deborah M (2014) Prevention science supplemental issue commentary promoting healthy sexual practices: what we have learned from 100 years of work. Prev Sci 15 Suppl 1:S78-80
Washburn, Isaac J; Capaldi, Deborah M (2014) Influences on Boys' Marijuana Use in High School: A Two-Part Random Intercept Growth Model. J Res Adolesc 24:117-130
Washburn, Isaac J; Capaldi, Deborah M; Kim, Hyoun K et al. (2014) Alcohol and marijuana use in early adulthood for at-risk men: time-varying associations with peer and partner substance use. Drug Alcohol Depend 140:112-7
Capaldi, Deborah M; Feingold, Alan; Kim, Hyoun K et al. (2013) Heterogeneity in growth and desistance of alcohol use for men in their 20s: prediction from early risk factors and association with treatment. Alcohol Clin Exp Res 37 Suppl 1:E347-55
Pears, Katherine C; Kim, Hyoun K; Capaldi, Deborah et al. (2013) Father-child transmission of school adjustment: a prospective intergenerational study. Dev Psychol 49:792-803
Wiesner, Margit; Capaldi, Deborah M; Kim, Hyoun K (2012) General versus specific predictors of male arrest trajectories: a test of the Moffitt and Patterson theories. J Youth Adolesc 41:217-28
Kerr, David C R; Capaldi, Deborah M; Owen, Lee D et al. (2011) Changes in At-Risk American Men's Crime and Substance Use Trajectories Following Fatherhood. J Marriage Fam 73:1101-1116
Kerr, D C R; Capaldi, D M (2011) Young men's intimate partner violence and relationship functioning: long-term outcomes associated with suicide attempt and aggression in adolescence. Psychol Med 41:759-69

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