Three Generational Study We proposes to study intergenerational transmission of alcohol, tobacco, and other drug use (ATOD) across three generations (G1, G2, and G3). We will use children in the Three Generational Study (3GS), a community sample consisting of up to two of the biological children (G3) of at-risk early adult men (G2) in the Oregon Youth Study (OYS). Multiple indicators of ATOD in G3 will be assessed, including age of onset of use and growth in use over early to midadolescence. A dynamic developmental systems approach focusing on both general pathway psychopathology and outcome-specific risk factors will be used to examine the developmental pathways of precursors (e.g., ATOD awareness) and of the emergence of these behaviors from early childhood to adolescence. Hypotheses regarding cross-generational congruence in the onset and growth of ATOD also will be examined, as well as the transmission of contextual risk and problematic behaviors across three generations, and parenting behaviors and peer influences across two generations. Additionally, the role of ATOD in the etiology of three public health problems;namely health-risking sexual behavior, suicidal thoughts and behaviors, and dating violence will be tested. The OYS men show high levels of antisocial behavior (at age 25 years, 42% had two or more arrests) and substance use (estimated 50% lifetime diagnoses for alcohol dependence or abuse and 50% prevalence of marijuana use in the mid 20s). The men are currently ages 36-38 years and, with their parents (G1), have been involved in the OYS since the G2 men were ages 9-10 years.
Specific Aims will be addressed through the collection and analysis of data that will expand the sample size for the early time points (ages 3 to 11 years) and extend the study to ages 19-20 years. Additionally, we will undertake secondary data analysis of the OYS, OYS-Couples Study, and 3GS extant data sets from the beginning of the proposed study period.

Public Health Relevance

This study will use prospective data across three generations to examine social mechanisms involved in the familial transmission of substance use and three related public health problems;namely health-risking sexual behavior, suicidal thoughts and behaviors, and dating violence. The study will examine the roles of general risk pathways (e.g., parent antisocial behavior and deviant peer association) as well as outcome-specific risk factors and processes (e.g., parental substance use) in the etiology of alcohol, tobacco, and other drug use. Developmental similarities or congruence across generations in the age of onset, course, and severity of substance use (e.g., age of onset, escalation) will be a particular focus of study.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Special Emphasis Panel (ZRG1-RPIA-N (09))
Program Officer
Etz, Kathleen
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Oregon Social Learning Center, Inc.
United States
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Capaldi, Deborah M; Kerr, David C R; Owen, Lee D et al. (2017) Intergenerational Associations in Sexual Onset: Mediating Influences of Parental and Peer Sexual Teasing and Youth Substance Use. J Adolesc Health 61:342-347
Kerr, David C R; Gini, Gianluca (2017) Prospective associations between peer teasing in childhood and young men's obesity. Obes Res Clin Pract 11:640-646
Kerr, David C R; Gini, Gianluca; Capaldi, Deborah M (2017) Young men's suicidal behavior, depression, crime, and substance use risks linked to childhood teasing. Child Abuse Negl 67:32-43
Capaldi, Deborah M; Tiberio, Stacey S; Kerr, David C R et al. (2016) The Relationships of Parental Alcohol Versus Tobacco and Marijuana Use With Early Adolescent Onset of Alcohol Use. J Stud Alcohol Drugs 77:95-103
Tiberio, Stacey S; Capaldi, Deborah M; Kerr, David C R et al. (2016) Parenting and the development of effortful control from early childhood to early adolescence: A transactional developmental model. Dev Psychopathol 28:837-53
Capaldi, Deborah M; Kerr, David C R; Eddy, J Mark et al. (2016) Understanding Persistence and Desistance in Crime and Risk Behaviors in Adulthood: Implications for Theory and Prevention. Prev Sci 17:785-93
Kerr, David C R; Tiberio, Stacey S; Capaldi, Deborah M (2015) Contextual risks linking parents' adolescent marijuana use to offspring onset. Drug Alcohol Depend 154:222-8
Washburn, Isaac J; Capaldi, Deborah M (2015) Heterogeneity in men's marijuana use in the 20s: adolescent antecedents and consequences in the 30s. Dev Psychopathol 27:279-91
Feingold, Alan; Capaldi, Deborah M; Owen, Lee D (2015) Proximal vs. distal predictors of alcohol use disorders and treatment utilization in at-risk men in early middle age. Compr Psychiatry 61:64-71
Capaldi, Deborah M; Tiberio, Stacey S; Washburn, Isaac J et al. (2015) Growth, Persistence, and Desistance of Alcohol Use for At-Risk Men in Their 30s. Alcohol Clin Exp Res 39:1203-11

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