The goal of this competing continuation project is to test models of the development and prevention of three inter-related antisocial problems in young adulthood: violence, substance abuse, and risky sexual behavior. Joint consideration of these three diverse problem domains holds promise because of the "syndemic" of parallel epidemics, comorbidity, similar epidemiology, and the possibility that isolated prevention efforts fail precisely because of the failure to consider joint effects. The investigators will test three major hypotheses: 1) these problems are comorbid across development, with early conduct problems leading to each adult outcome;2) a comorbid antisocial behavior pattern develops as a dynamic cascade, in which early risk factors dispose a child to later risk factors, which lead to problem outcomes. The model posits gene-environment interactions that are mediated through acquired social information-processing patterns. Domain-specific outcomes also develop through specific affordance experiences;and 3) random assignment to preventive intervention will reduce the probability of each of antisocial outcome in adulthood, with moderation by genetic and early-life factors and mediation by intervention effects on early conduct problems and social-cognitive patterns. The samples come from two independent, ongoing prospective studies of conduct disorder, the Child Development Project (CDP) and Fast Track (FT). The CDP has followed a community sample of 585 preschool males and females who are now 26 years old, with high (90 percent) retention after 22 years. The FT Project is a multi-site randomized clinical trial, in which 891 early-starting, conduct-problem youth (31 percent girls;51 percent African-American) were assigned in kindergarten to receive (or not) a 10-year comprehensive intervention to prevent conduct disorder and have been followed through age 24 with high (83 percent) retention of participants. In the proposed project, identical measures of violence, substance-use problems, and risky sexual behaviors will be assessed in the CDP through age 31 and in FT through age 29. Growth analyses, confirmatory factor analyses, and structural equation modeling will test hypotheses. Relevance to public health: This project will contribute to the discovery of ways to prevent young adult antisocial problems, including violence, substance abuse, and risky sexual behaviors.

Public Health Relevance

This project will increase our understanding of how problems of violence, substance abuse, and risky sexual behavior develop across the lifespan and relate to each other. It will test the efficacy of a long-term intervention to prevent these problems in young adulthood.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA016903-10
Application #
8505435
Study Section
Special Emphasis Panel (ZRG1-RPHB-A (02))
Program Officer
Lloyd, Jacqueline
Project Start
2003-09-20
Project End
2014-05-31
Budget Start
2013-07-01
Budget End
2014-05-31
Support Year
10
Fiscal Year
2013
Total Cost
$647,100
Indirect Cost
$229,691
Name
Duke University
Department
Miscellaneous
Type
Schools of Arts and Sciences
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
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Schwartz, David; Lansford, Jennifer E; Dodge, Kenneth A et al. (2015) Peer victimization during middle childhood as a lead indicator of internalizing problems and diagnostic outcomes in late adolescence. J Clin Child Adolesc Psychol 44:393-404
Lansford, Jennifer E; Dodge, Kenneth A; Fontaine, Reid Griffith et al. (2014) Peer rejection, affiliation with deviant peers, delinquency, and risky sexual behavior. J Youth Adolesc 43:1742-51
Kokko, Katja; Simonton, Sharon; Dubow, Eric et al. (2014) Country, sex, and parent occupational status: moderators of the continuity of aggression from childhood to adulthood. Aggress Behav 40:552-67
Lansford, Jennifer E; Yu, Tianyi; Pettit, Gregory S et al. (2014) Pathways of Peer Relationships from Childhood to Young Adulthood. J Appl Dev Psychol 35:111-117
Rudolph, Karen D; Lansford, Jennifer E; Agoston, Anna M et al. (2014) Peer victimization and social alienation: predicting deviant peer affiliation in middle school. Child Dev 85:124-39
Carré, Justin M; Iselin, Anne-Marie R; Welker, Keith M et al. (2014) Testosterone reactivity to provocation mediates the effect of early intervention on aggressive behavior. Psychol Sci 25:1140-6
Petersen, Isaac T; Bates, John E; D'Onofrio, Brian M et al. (2013) Language ability predicts the development of behavior problems in children. J Abnorm Psychol 122:542-57
Makin-Byrd, Kerry; Bierman, Karen L; Conduct Problems Prevention Research Group (2013) Individual and family predictors of the perpetration of dating violence and victimization in late adolescence. J Youth Adolesc 42:536-50

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