One of the most profound forms of chronic stress for the developing child is being subjected to abuse and neglect. As chronically stressed maltreated children develop, they are at substantial risk for substance use, abuse, and addiction. Thus, investigation of chronically stressed maltreated children provides a natural experiment for delineating the development of stress-induced vulnerabilities for substance use and abuse. Chronic stress exerts diverse negative effects on psychological and biological development, and understanding the impact of chronic stress on multiple developmental systems is critical for determining susceptibility to drug abuse. In this investigation, 400 chronically stressed maltreated 10-to 12-year-old children will be contrasted with 400 nonmaltreated children in order to determine the effects of chronic stress on neuroendocrine regulation, attention networks, executive function abilities, and emotion regulation capacities. Children will participate in a research day camp, and peer relations, personality organization, psychopathology, and substance use also will be assessed. Evaluations of child functioning in school will be obtained from classroom teachers, and the children's mothers also will provide information on additional sources of stress in the home. Based on a developmental psychopathology perspective and utilizing a person-centered approach, we expect to identify different forms of stress-induced vulnerability for substance use. The extent of aggregation of these forms of vulnerability within chronically stressed maltreated children who exhibit different types of personality organization and psychopathology will be investigated. The effects of additional forms of stress exposure and of a drug use promoting context on the susceptibility to substance use among children with different forms of vulnerability also will be investigated. The findings will hold promise for informing prevention and intervention initiatives.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
3R01DA017741-04S1
Application #
7433629
Study Section
Special Emphasis Panel (ZDA1-KXN-G (05))
Program Officer
Schulden, Jeffrey D
Project Start
2004-08-05
Project End
2009-05-31
Budget Start
2007-06-01
Budget End
2008-05-31
Support Year
4
Fiscal Year
2007
Total Cost
$8,041
Indirect Cost
Name
University of Rochester
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
041294109
City
Rochester
State
NY
Country
United States
Zip Code
14627
Warmingham, Jennifer M; Handley, Elizabeth D; Rogosch, Fred A et al. (2018) Identifying maltreatment subgroups with patterns of maltreatment subtype and chronicity: A latent class analysis approach. Child Abuse Negl :
Alto, Michelle; Handley, Elizabeth; Rogosch, Fred et al. (2018) Maternal relationship quality and peer social acceptance as mediators between child maltreatment and adolescent depressive symptoms: Gender differences. J Adolesc 63:19-28
Handley, Elizabeth D; Rogosch, Fred A; Cicchetti, Dante (2017) From child maltreatment to emerging adult problem drinking: Identification of a multilevel internalizing pathway among African American youth. Dev Psychopathol 29:1807-1821
Cowell, Raquel A; Cicchetti, Dante; Rogosch, Fred A et al. (2015) Childhood maltreatment and its effect on neurocognitive functioning: Timing and chronicity matter. Dev Psychopathol 27:521-33
Vachon, David D; Krueger, Robert F; Rogosch, Fred A et al. (2015) Assessment of the Harmful Psychiatric and Behavioral Effects of Different Forms of Child Maltreatment. JAMA Psychiatry 72:1135-42
Handley, Elizabeth D; Rogosch, Fred A; Cicchetti, Dante (2015) Developmental pathways from child maltreatment to adolescent marijuana dependence: Examining moderation by FK506 binding protein 5 gene (FKBP5). Dev Psychopathol 27:1489-502
Thibodeau, Eric L; Cicchetti, Dante; Rogosch, Fred A (2015) Child maltreatment, impulsivity, and antisocial behavior in African American children: Moderation effects from a cumulative dopaminergic gene index. Dev Psychopathol 27:1621-36
Cicchetti, Dante; Rogosch, Fred A (2014) Genetic moderation of child maltreatment effects on depression and internalizing symptoms by serotonin transporter linked polymorphic region (5-HTTLPR), brain-derived neurotrophic factor (BDNF), norepinephrine transporter (NET), and corticotropin releasin Dev Psychopathol 26:1219-39
Cicchetti, Dante; Rogosch, Fred A; Hecht, Kathryn F et al. (2014) Moderation of maltreatment effects on childhood borderline personality symptoms by gender and oxytocin receptor and FK506 binding protein 5 genes. Dev Psychopathol 26:831-49
Hecht, Kathryn F; Cicchetti, Dante; Rogosch, Fred A et al. (2014) Borderline personality features in childhood: the role of subtype, developmental timing, and chronicity of child maltreatment. Dev Psychopathol 26:805-15

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