Childhood maltreatment (i.e., physical, sexual or emotional abuse by parents, peers or siblings, physical and emotional neglect) has an enormous impact on risk for substance abuse and dependence. The Adverse Childhood Experience Study reported that exposure to maltreatment-related adversity accounted for 64% of the population attributable risk for substance abuse. Understanding this association may be crucial to our efforts to prevent, preempt or treat drug abuse. During the previous funding period we conducted a series of studies to better understand the association between childhood maltreatment and substance use. We found in cross-sectional studies that exposure to physical maltreatment was a more significant risk factor for high levels of drug and alcohol use than emotional maltreatment, and that physical maltreatment (but not emotional maltreatment) was associated with marked alterations in T2-relaxation time (an indirect measures of cerebral blood volume assessed by MRI) in major components of the ascending dopamine system. T2-relaxation time in two components (dorsolateral prefrontal and anterior cingulate cortex) correlated with degree of drug and alcohol use. Further we found a strong statistical relationship between the size of the first lobule (lingula) of the cerebellar vermis in physically maltreated subjects and degree of substance use. We also found that substance use by maltreated individuals spiked at 20-21 years of age. The key aims of the proposed study are to test in a prospective study whether T2-relaxation time in dorsolateral prefrontal and anterior cingulate cortex, and large lingula size can predict degree of drug and alcohol use by maltreated individuals. Moreover, we will test the hypothesis that type and timing of exposure to maltreatment matters, and that there are sensitive periods when exposure to specific types of maltreatment are most likely to effect the development of these brain regions? and to increase risk for drug abuse. This information will shed new light on our understanding of the relationship between maltreatment and drug abuse by examining the phenomenon from a developmental neuroscience perspective. These studies may provide the critical insights necessary to design programs to protect children during their most vulnerable periods, and to develop preemptive strategies to aid exposed individuals before their vulnerability becomes manifest.

Public Health Relevance

Childhood maltreatment is a leading risk factor for drug abuse. We will study the problem from a developmental neuroscience perspective, and test the hypothesis that maltreatment during sensitive periods affects the development of dopamine system and cerebellum, and that alterations in these regions can predict risk for high levels of drug use in a prospective longitudinal study.

Agency
National Institute of Health (NIH)
Type
Research Project (R01)
Project #
5R01DA017846-08
Application #
8604699
Study Section
Risk, Prevention and Intervention for Addictions Study Section (RPIA)
Program Officer
Gordon, Harold
Project Start
Project End
Budget Start
Budget End
Support Year
8
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Mclean Hospital
Department
Type
DUNS #
City
Belmont
State
MA
Country
United States
Zip Code
02478
Teicher, Martin H; Samson, Jacqueline A (2016) Annual Research Review: Enduring neurobiological effects of childhood abuse and neglect. J Child Psychol Psychiatry 57:241-66
Teicher, Martin H; Ohashi, Kyoko; Lowen, Steven B et al. (2015) Mood dysregulation and affective instability in emerging adults with childhood maltreatment: An ecological momentary assessment study. J Psychiatr Res 70:1-8
Khan, Alaptagin; McCormack, Hannah C; Bolger, Elizabeth A et al. (2015) Childhood Maltreatment, Depression, and Suicidal Ideation: Critical Importance of Parental and Peer Emotional Abuse during Developmental Sensitive Periods in Males and Females. Front Psychiatry 6:42
Schalinski, Inga; Teicher, Martin H (2015) Type and timing of childhood maltreatment and severity of shutdown dissociation in patients with schizophrenia spectrum disorder. PLoS One 10:e0127151
Teicher, Martin H; Parigger, Angelika (2015) The 'Maltreatment and Abuse Chronology of Exposure' (MACE) scale for the retrospective assessment of abuse and neglect during development. PLoS One 10:e0117423
Pechtel, Pia; Lyons-Ruth, Karlen; Anderson, Carl M et al. (2014) Sensitive periods of amygdala development: the role of maltreatment in preadolescence. Neuroimage 97:236-44
Polcari, Ann; Rabi, Keren; Bolger, Elizabeth et al. (2014) Parental verbal affection and verbal aggression in childhood differentially influence psychiatric symptoms and wellbeing in young adulthood. Child Abuse Negl 38:91-102
Teicher, Martin H; Anderson, Carl M; Ohashi, Kyoko et al. (2014) Childhood maltreatment: altered network centrality of cingulate, precuneus, temporal pole and insula. Biol Psychiatry 76:297-305
Shin, Sunny H; Miller, Daniel P; Teicher, Martin H (2013) Exposure to childhood neglect and physical abuse and developmental trajectories of heavy episodic drinking from early adolescence into young adulthood. Drug Alcohol Depend 127:31-8
Teicher, Martin H; Samson, Jacqueline A (2013) Childhood maltreatment and psychopathology: A case for ecophenotypic variants as clinically and neurobiologically distinct subtypes. Am J Psychiatry 170:1114-33

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