Adolescent substance use (SU) is of great concern in part because early patterns of SU often presage later negative outcomes. One pathway to SU involves a progression from childhood behavior problems to affiliations with deviant peers, which are key proximal determinants of initiation and escalation of adolescent SU. Moreover, reciprocal influences between individuals and their social environment are posited to affect the progression to SU. Limited research has considered the role of internalizing behavior problems and their co-occurrence with externalizing problems in this pathway. This is a notable omission because externalizing and internalizing problems often co-occur. Pure and co-occurring behavior problems may influence SU through different mechanisms, and if so, then preventive interventions need to be tailored accordingly. In addition, brain development during adolescence is thought to result in transient changes in appetitive motivation, which may increase vulnerability to risky contexts. There is a clear need for research that integrates developmental changes in motivation and social contextual influences to better understand vulnerability to and protection from initiation and escalation of adolescent SU. Such research will inform the development of comprehensive preventive interventions for at-risk youth. The proposed research will examine how shifts in motivational aspects of temperament interact with childhood behavior problems and peer context to influence SU. A community sample of 410 11-12 year old children will be assessed in a 3- wave longitudinal study, providing an opportunity to examine how changes in these constructs contribute to the initiation and early escalation of SU. Temperament profiles based on approach, inhibition, and self- regulation will be assessed using laboratory tasks, physiological indicators, and caregiver reports. Peer influences will be assessed using child and peer reports. We will examine: 1) the reciprocal relation between problem behavior and affiliation with peers who support SU;2) reciprocal mediational pathways among affiliation with peers who support SU, problem behavior, and SU;and 3) whether motivational profiles and profile transitions moderate the proposed mediational paths.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-RPHB-H (90))
Program Officer
Weinberg, Naimah Z
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
State University of New York at Buffalo
Schools of Arts and Sciences
United States
Zip Code
Colder, Craig R; Frndak, Seth; Lengua, Liliana J et al. (2017) Internalizing and Externalizing Problem Behavior: a Test of a Latent Variable Interaction Predicting a Two-Part Growth Model of Adolescent Substance Use. J Abnorm Child Psychol :
Colder, Craig R; Shyhalla, Kathleen; Frndak, Seth et al. (2017) The Prospective Association Between Internalizing Symptoms and Adolescent Alcohol Involvement and the Moderating Role of Age and Externalizing Symptoms. Alcohol Clin Exp Res 41:2185-2196
Scalco, Matthew D; Colder, Craig R (2016) Trajectories of marijuana use from late childhood to late adolescence: Can Temperament × Experience interactions discriminate different trajectories of marijuana use? Dev Psychopathol :1-16
Scalco, Matthew D; Meisel, Samuel N; Colder, Craig R (2016) Misperception and accurate perception of close friend substance use in early adolescence: Developmental and intervention implications. Psychol Addict Behav 30:300-11
Meisel, Samuel N; Colder, Craig R; Hawk, Larry W (2015) The moderating role of cognitive capacities in the association between social norms and drinking behaviors. Alcohol Clin Exp Res 39:1049-56
Meisel, Samuel N; Colder, Craig R (2015) Social Goals and Grade as Moderators of Social Normative Influences on Adolescent Alcohol Use. Alcohol Clin Exp Res 39:2455-62
Scalco, Matthew D; Trucco, Elisa M; Coffman, Donna L et al. (2015) Selection and Socialization Effects in Early Adolescent Alcohol Use: A Propensity Score Analysis. J Abnorm Child Psychol 43:1131-43
Scalco, Matthew D; Colder, Craig R; Hawk, Larry W et al. (2014) Internalizing and externalizing problem behavior and early adolescent substance use: a test of a latent variable interaction and conditional indirect effects. Psychol Addict Behav 28:828-40
Trucco, Elisa M; Colder, Craig R; Wieczorek, William F et al. (2014) Early adolescent alcohol use in context: how neighborhoods, parents, and peers impact youth. Dev Psychopathol 26:425-36
Pardee, Carolyn Speidel; Colder, Craig R; Bowker, Julie C (2014) Dynamic associations among alcohol use and anxiety symptoms in early adolescence. Psychol Addict Behav 28:1246-52

Showing the most recent 10 out of 21 publications