This is a renewal of a Research Project Grant R01DA019912 "Parallel MRI for High Field Neuroimaging" for the development of techniques for rapid, artifact free functional MRI (fMRI). During the previous funding period numerous methods were developed for correcting image artifacts using "parallel transmission" (PTX) and "tailored RF" (TRF) pulses. These artifacts include RF field (B1+) inhomogeneity and susceptibility artifacts (B0 inhomogeneity). B1+ inhomogeneity produces large intensity variations in images and B0 inhomogeneity creates large signal voids that obscure many brain regions crucial to understanding disease in the brain including addictive disorders. Recently Simultaneous Multi-Slice (SMS) imaging has been shown to be a promising technique for ultra-fast fMRI. SMS imaging excites multiple overlapping slices that are unfolded during reconstruction using multiple receiver coils. SMS imaging is significant for numerous applications including fMRI because it allows for increased acquisition speed on the order of four to eight. Although SMS imaging is gaining popularity, there has been little work done on improving SMS RF pulse excitations, extending it to PTX, and to non-Cartesian spiral data acquisitions. Improved pulse designs and PTX will allow for SMS excitations with reduced B1+ and B0 inhomogeneity. Spiral imaging has a highly efficient gradient usage allowing for shorter acquisition times and further increases in acquisition speed. This renewal will focus on these innovations to SMS imaging at 3T. The PI has assembled a team of internationally recognized scientists including Dr. Lawrence Wald at Massachusetts General Hospital, who is a world expert in PTX coil design and SMS imaging, and Dr. William Grissom at Vanderbilt University, who is a top researcher in PTX and RF pulse design. We will pursue the following Specific Aims: (1) Develop SMS excitations for PTX;(2) develop SMS TRF pulses that compensate for B1+ and B0 inhomogeneity;(3) develop non-Cartesian spiral acquisitions and reconstructions for ultra-fast SMS imaging;and (4) validate the methods with fMRI in control subjects.

Public Health Relevance

This is a renewal of a Research Project Grant R01DA019912 Parallel MRI for High Field Neuroimaging for the development of rapid, artifact free functional MRI (fMRI) methodology for brain disease research including drug addiction. During the previous R01 funding period numerous innovations were developed most notably using novel techniques called parallel transmission and tailored RF pulses for correcting image artifacts at high field. During the new funding period we propose several novel methods for simultaneous multi-slice (SMS) fMRI. SMS imaging holds great promise for numerous MRI applications including fMRI because it allows for high (factor four and greater) increases in acquisition speed. We propose to develop parallel transmission, tailored RF pulse, and spiral sampling methodology for ultra-fast artifact free SMS imaging. We will validate these methods using fMRI.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
2R01DA019912-06
Application #
8578828
Study Section
Biomedical Imaging Technology Study Section (BMIT)
Program Officer
Bjork, James M
Project Start
2005-07-01
Project End
2018-05-31
Budget Start
2013-09-15
Budget End
2014-05-31
Support Year
6
Fiscal Year
2013
Total Cost
$412,860
Indirect Cost
$68,383
Name
University of Hawaii
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
965088057
City
Honolulu
State
HI
Country
United States
Zip Code
96822
Sharma, Anuj; Bammer, Roland; Stenger, V Andrew et al. (2015) Low peak power multiband spokes pulses for B1 (+) inhomogeneity-compensated simultaneous multislice excitation in high field MRI. Magn Reson Med 74:747-55
Guérin, Bastien; Setsompop, Kawin; Ye, Huihui et al. (2015) Design of parallel transmission pulses for simultaneous multislice with explicit control for peak power and local specific absorption rate. Magn Reson Med 73:1946-53
Deng, Weiran; Boada, Fernando; Poser, Benedikt A et al. (2015) Iterative projection onto convex sets for quantitative susceptibility mapping. Magn Reson Med 73:697-703
Zahneisen, Benjamin; Poser, Benedikt A; Ernst, Thomas et al. (2014) Simultaneous Multi-Slice fMRI using spiral trajectories. Neuroimage 92:8-18
Harkins, Kevin D; Does, Mark D; Grissom, William A (2014) Iterative method for predistortion of MRI gradient waveforms. IEEE Trans Med Imaging 33:1641-7
Zahneisen, Benjamin; Poser, Benedikt A; Ernst, Thomas et al. (2014) Three-dimensional Fourier encoding of simultaneously excited slices: generalized acquisition and reconstruction framework. Magn Reson Med 71:2071-81
Poser, Benedikt A; Anderson, Robert James; Guerin, Bastien et al. (2014) Simultaneous multislice excitation by parallel transmission. Magn Reson Med 71:1416-27
Poser, Benedikt A; Barth, Markus; Goa, Pal-Erik et al. (2013) Single-shot echo-planar imaging with Nyquist ghost compensation: interleaved dual echo with acceleration (IDEA) echo-planar imaging (EPI). Magn Reson Med 69:37-47
Deng, Weiran; Yang, Cungeng; Stenger, V Andrew (2011) Accelerated multidimensional radiofrequency pulse design for parallel transmission using concurrent computation on multiple graphics processing units. Magn Reson Med 65:363-9
Yang, Cungeng; Deng, Weiran; Stenger, V Andrew (2011) Simple analytical dual-band spectral-spatial RF pulses for B(1) + and susceptibility artifact reduction in gradient echo MRI. Magn Reson Med 65:370-6

Showing the most recent 10 out of 13 publications