The ongoing HIV epidemic increasingly involves non-injection drug use (NIDU). In HIV-infected individuals, particularly vulnerable populations such as low-income minority patients in HIV primary care, reducing NIDU is important to improve overall health and HAART adherence, and to reduce sexual transmission of HIV. A barrier to progress in NIDU reduction for this complex population has been the lack of effective interventions that make limited demands on staff and resources. An intervention designed to overcome this barrier combines Motivational Interviewing (MI) with automated telephone technology (HealthCall). The intervention begins with a counselor administering a brief MI session targeting NIDU. Then, with little additional staff time, """"""""HealthCall"""""""" extends the intervention through patient use of Interactive Voice Response (IVR) technology, which provides behavioral self-monitoring of NIDU and other target behaviors. Patients make brief daily calls to the IVR for 60 days. At 30 and 60 days, MI counselors meet with patients and give them brief personalized feedback, discussing a graph on their drug use generated from the IVR data. Thus, HealthCall serves as a """"""""clinician-extender"""""""" of the brief MI. A successful randomized pilot study of MI+HealthCall among low-SES, minority patients with active non- injection drug use in a large, metropolitan, HIV primary care clinic demonstrated acceptability and feasibility of MI+HealthCall, and, compared to MI-only, suggested efficacy of MI+HealthCall in reducing drug use and improving HAART adherence. A 3-arm randomized controlled trial (RCT) of MI+HealthCall is proposed in the same setting and patient population. In this RCT, 390 patients will be randomized to (1) MI+HealthCall, (2) MI-only or (3) educational control. Evaluations will be done at baseline, 30 and 60 days, and at 3, 6 and 12 months. Main outcomes are reduction in use of primary drug (non-injection cocaine, heroin or methamphetamine), improved HAART adherence, and reduced sexual risk behavior. Mediators (motivation to change and self-efficacy) and moderators (e.g., depression) will be explored. Achieving study aims could help reduce NIDU, improve HAART adherence and reduce sexual risk behaviors in HIV primary care patients. More broadly, a novel, technologically-enhanced intervention would be added to the treatment literature that could change concepts about the ratio of required clinician time to the duration of patient participation in an intervention. This proposal is responsive to NIDA PA-09-236 """"""""HIV/AIDS, Drug Use, and Vulnerable Populations in the US"""""""".

Public Health Relevance

Among HIV-infected individuals, non-injection drug use (NIDU) is associated with poor HIV medication adherence, greater HIV/AIDS risk behaviors, and increasing non-AIDS mortality. Thus, reducing NIDU among HIV-infected individuals is critical to their survival and to limiting the spread of HIV. We propose to study the efficacy of a technologically-enhanced brief intervention to reduce NIDU in HIV primary care patients that demands little from busy medical staff and is well-accepted by patients.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Behavioral and Social Consequences of HIV/AIDS Study Section (BSCH)
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Aklin, Will
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New York State Psychiatric Institute
New York
United States
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Delker, Erin; Aharonovich, Efrat; Hasin, Deborah (2016) Interviewer-administered TLFB vs. self-administered computerized (A-CASI) drug use frequency questions: a comparison in HIV-infected drug users. Drug Alcohol Depend 161:29-35
Elliott, Jennifer C; Delker, Erin; Wall, Melanie M et al. (2016) The Importance of Context: Neighborhood Drinking Norms and Heavy Drinking Among HIV Patients. J Acquir Immune Defic Syndr 72:e55-7
Elliott, Jennifer C; Stohl, Malka; Aharonovich, Efrat et al. (2016) Reasons for drinking as predictors of alcohol involvement one year later among HIV-infected individuals with and without hepatitis C. Ann Med 48:634-640
Elliott, Jennifer C; Aharonovich, Efrat; Hasin, Deborah S (2015) Post-treatment drinking among HIV patients: Relationship to pre-treatment marijuana and cocaine use. Drug Alcohol Depend 151:115-20
Aharonovich, Efrat; Stohl, Malka; Ellis, James et al. (2014) Commitment strength, alcohol dependence and HealthCall participation: effects on drinking reduction in HIV patients. Drug Alcohol Depend 135:112-8
Elliott, Jennifer C; Aharonovich, Efrat; O'Leary, Ann et al. (2014) Perceived medical risks of drinking, alcohol consumption, and hepatitis C status among heavily drinking HIV primary care patients. Alcohol Clin Exp Res 38:3052-9
Elliott, Jennifer C; Aharonovich, Efrat; O'Leary, Ann et al. (2014) Drinking motives as prospective predictors of outcome in an intervention trial with heavily drinking HIV patients. Drug Alcohol Depend 134:290-5
Keyes, Katherine M; Shmulewitz, Dvora; Greenstein, Eliana et al. (2014) Exposure to the Lebanon War of 2006 and effects on alcohol use disorders: the moderating role of childhood maltreatment. Drug Alcohol Depend 134:296-303
Elliott, Jennifer C; Aharonovich, Efrat; Hasin, Deborah S (2014) Reasons for limiting drinking in an HIV primary care sample. Alcohol Clin Exp Res 38:1720-7
Elliott, Jennifer C; Aharonovich, Efrat; O'Leary, Ann et al. (2014) Drinking motives among HIV primary care patients. AIDS Behav 18:1315-23

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