Adolescence is a critical period of neurological, biological, and social growth during the transition from childhood to adulthood. Healthy adolescence is defined by an increasing ability to control impulsive behavior. Deviations from normal development that are produced by substance use and environmental factors are thought to contribute to poor impulse control. Preadolescent problems with impulse control and family histories of substance use disorders appear to increase the risk of earlier substance use initiation during adolescence. It is unknown whether poor impulse control contributes to, or is the result of, substance use and whether poor impulse control and substance use interact across adolescent development to produce increasingly negative outcomes. During a 5-year longitudinal study, we will determine how preadolescent impulse control predicts, and/or later substance use involvement alters, development of adolescent impulse control. We will recruit 360 preadolescent boys and girls (ages 10-12) with and without family histories of substance use disorders, none of whom have initiated regular substance use. Adolescents will complete assessments at study entry and again every 6 months through middle adolescence (from ages 10 through 17), when the risk of developing substance use is heightened. We will monitor changes in substance use involvement, environmental stressors, physical maturation, and impulse control. The project will examine these complex developmental influences on impulse control and substance use involvement by: (1) determining to what extent preadolescent levels of impulse control differ as a function of family history of substance use disorders;(2) determining to what extent preadolescent levels of impulse control predict regular substance use;(3) characterizing impulse control of normal adolescence, and how this development differs with varying levels of substance use;(4) determining how the development of impulse control among substance users is related to the progression of substance use involvement;(5) determining the relative influence of family histories of substance use disorders, substance use involvement, environmental stressors, and maturation on impulse control development across adolescence;(6) determining if there is a reciprocal relationship between impulse control and substance use involvement, such that they have increasingly negative behavioral outcomes that affect each other during adolescence;and (7) testing the relationships of impulse control, family history of substance use disorders, environmental stressors, and substance use involvement within the context of two leading models. By carrying out these aims, we will determine when, how, and to what extent individual differences in these factors contribute to the initiation and progression of substance use;how subsequent substance use affects development of impulse control;and whether our findings support two leading theoretical models of adolescent substance use involvement.

Public Health Relevance

This study will advance our understanding of how the development of impulse control and environmental influences occurring during adolescence interact with one another to lead to problems with substance use. Understanding these relationships will aid in the identification of the antecedents and consequences of substance use on key processes of adolescent development. The advancement of better prevention programs and substance use treatments are dependent on a gaining a better understanding of these complex relationships.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA026868-04
Application #
8433399
Study Section
Special Emphasis Panel (ZRG1-BBBP-R (02))
Program Officer
Sirocco, Karen
Project Start
2010-05-15
Project End
2015-02-28
Budget Start
2013-03-01
Budget End
2014-02-28
Support Year
4
Fiscal Year
2013
Total Cost
$565,753
Indirect Cost
$171,379
Name
University of Texas Health Science Center San Antonio
Department
Psychiatry
Type
Schools of Medicine
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Charles, Nora E; Ryan, Stacy R; Bray, Bethany C et al. (2016) Altered developmental trajectories for impulsivity and sensation seeking among adolescent substance users. Addict Behav 60:235-41
Mathias, Charles W; Charles, Nora E; Liang, Yuanyuan et al. (2016) Pubertal Maturation Compression and Behavioral Impulsivity among Boys at Increased Risk for Substance Use. Addict Disord Their Treat 15:61-73
Friedman, Carly K; Ryan, Stacy R; Charles, Nora E et al. (2016) Child Problems as a Moderator of Relations Between Maternal Impulsivity and Family Environment in a High-Risk Sample. Subst Use Misuse 51:1264-73
Dougherty, Donald M; Olvera, Rene L; Acheson, Ashley et al. (2016) Acute effects of methylphenidate on impulsivity and attentional behavior among adolescents comorbid for ADHD and conduct disorder. J Adolesc 53:222-230
Acheson, Ashley; Lake, Sarah L; Bray, Bethany C et al. (2016) Early Adolescent Trajectories of Impulsiveness and Sensation Seeking in Children of Fathers with Histories of Alcohol and Other Substance Use Disorders. Alcohol Clin Exp Res 40:2622-2630
Ryan, Stacy R; Friedman, Carly K; Liang, Yuanyuan et al. (2016) Family Functioning as a Mediator of Relations between Family History of Substance Use Disorder and Impulsivity. Addict Disord Their Treat 15:17-24
Charles, Nora E; Mathias, Charles W; Acheson, Ashley et al. (2015) Increased Pre- and Early-Adolescent Stress in Youth with a Family History of Substance Use Disorder and Early Substance Use Initiation. J Youth Adolesc 44:1954-67
Dougherty, Donald M; Lake, Sarah L; Mathias, Charles W et al. (2015) Behavioral Impulsivity and Risk-Taking Trajectories Across Early Adolescence in Youths With and Without Family Histories of Alcohol and Other Drug Use Disorders. Alcohol Clin Exp Res 39:1501-9
Mathias, Charles W; Duffing, Tiffany M; Ashley, Acheson et al. (2015) Aggression as a Predictor of Early Substance Use Initiation among Youth with Family Histories of Substance Use Disorders. Addict Disord Their Treat 14:230-240
Acheson, Ashley; Tagamets, Malle A; Winkler, Anderson et al. (2015) Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance-use disorders performing a go/no-go task. Brain Behav 5:e00352

Showing the most recent 10 out of 17 publications