The aims of this study are to advance Type 2 translational science and theory building through targeting risk and protective factors for substance use and sexual risk (e.g., HIV/AIDS) among 8th and 9th grade South African youth. We will focus on factors that influence implementation fidelity of HealthWise South Africa: Life Skills for Adolescents, an evidence-based substance use and sexual risk prevention program that fills an educational vacuum in the high school curriculum at an age when students are at very high risk for initiating substance abuse and sexual risk. HealthWise, which has systematically evolved since 2000 through phases of pilot testing and an efficacy trial, will be disseminated to 56 high schools in South Africa beginning in February 2011. This presents us with an unprecedented opportunity to conduct an innovative randomized experiment to investigate three key independent variables hypothesized to influence implementation fidelity: teacher training;teacher structure, support and supervision;and enhancement of school environment. A cost analysis will also be conducted. Longitudinal outcome and process data will be collected from teachers, principals and students. Because of its scope and innovativeness, this has potential to be a landmark Type 2 translation study that will have implications for other research on school-based prevention programs that attempt to move to scale and translate to conditions that are outside of research-driven contexts. It will also address a critical gap in sexual risk and substance use prevention among South African youth at a particularly vulnerable time.

Public Health Relevance

This proposal is aimed at reducing adolescent risk for sexual risk and substance use through understanding the role of effective implementation strategies. The research involves an integrated approach to prevention which has proven to be efficacious in a previous trial. This proposed translational trial will be conducted with 56 diverse high schools in South Africa, where the incidence of HIV/AIDS is among the highest in the world. If this trial is successful, the approach used in this trial could be a model for South Africa and other countries.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA029084-03
Application #
8278692
Study Section
Community-Level Health Promotion Study Section (CLHP)
Program Officer
Sims, Belinda E
Project Start
2010-08-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
3
Fiscal Year
2012
Total Cost
$502,472
Indirect Cost
$73,428
Name
Pennsylvania State University
Department
Miscellaneous
Type
Schools of Allied Health Profes
DUNS #
003403953
City
University Park
State
PA
Country
United States
Zip Code
16802
Weybright, Elizabeth H; Caldwell, Linda L; Ram, Nilam et al. (2014) The Dynamic Association between Healthy Leisure and Substance Use in South African Adolescents: A State and Trait Perspective. World Leis J 56:99-109
Lai, Mary H; Graham, John W; Smith, Edward A et al. (2013) Linking Life Skills and Norms With Adolescent Substance Use and Delinquency in South Africa. J Res Adolesc 23:128-137
Coffman, Donna L; Caldwell, Linda L; Smith, Edward A (2012) Introducing the at-risk average causal effect with application to HealthWise South Africa. Prev Sci 13:437-47