This project has been designed to understand the epidemiology of the risks for transmission of the hepatitis C virus (HCV) through unsafe drug injection and evaluate methods to reduce transmission. The study protocol applies an interdisciplinary epidemiological approach that fuses into laboratory-based research the real-world observations on drug injection practices to analyze (1) the potential for HCV transmission resulting from the use of HCV-contaminated injection equipment, (2) the duration of HCV viability in injection equipment of equipment, (3) the potential for disinfectants to inactivate HCV, and (4) the potential for exposure to infectious HCV in various drug preparation and injection practices common in parts of the world where the HCV epidemic among injection drugs users is still rapidly increasing. The laboratory assay takes advantage of a newly developed in vitro assay for HCV proliferation that employs whole virions and the handling of injection paraphernalia in the laboratory will be informed by oversight from medical anthropologists who have first-hand observational experience of drug injection practices. Epidemiological analysis and dissemination of the results will be used to inform prevention programs and individuals at risk for transmitting or becoming infected with HCV about the step that can be taken to reduce transmission.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
3R01DA030420-03S1
Application #
8774385
Study Section
Program Officer
Lao, Guifang
Project Start
2014-01-01
Project End
2014-12-31
Budget Start
2014-01-01
Budget End
2014-12-31
Support Year
3
Fiscal Year
2014
Total Cost
$115,995
Indirect Cost
$40,917
Name
Yale University
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520