Numerous adverse health consequences arise from tobacco and alcohol use, though the pathways of tobacco and alcohol use from early adolescence into adulthood and the factors that best predict these pathways are not well understood. Individuals diagnosed with Attention Deficit Hyperactivity Disorder (ADHD) smoke and use alcohol at higher proportions than those without ADHD. Moreover, ADHD symptoms (i.e., hyperactivity- impulsivity [HI], inattention [IN]) below the threshold necessary for clinical diagnosis increase the risk of cigarette smoking. A clearer understanding of the developmental relationship between these symptom domains and substance use has the potential to elucidate the potential etiology of smoking and problem drinking as well as inform treatment and prevention approaches in both clinical groups and in the general population. Using traditional and innovative/advanced analytic methods for identifying population subgroups and dynamic properties of substance use (factor mixture modeling, latent curve modeling, and growth mixture modeling), we will analyze extant longitudinal data that contains information on history of HI and IN symptoms and tobacco and alcohol use outcomes. Two nationally representative databases will be used (The National Longitudinal Survey of Adolescent Health-Add Health and Panel Survey of Income Dynamics - Child Development Supplement/Transition to Adulthood - PSID-CDS/TA). The investigative team has expertise in the areas of ADHD, addiction, behavioral epidemiology and longitudinal data analysis and thus, is well poised to undertake the proposed research. The successful completion of this proposal will result in refined knowledge concerning the influence of HI and IN symptoms on substance use from adolescence to young adulthood. Such knowledge is necessary for effective preventive intervention planning and implementation.
Tobacco and excessive alcohol consumption are associated with adverse health outcomes including a number of cancers. The pathways of tobacco and alcohol use from early adolescence into adulthood and the factors that best predict these pathways are not well understood. However, symptoms of Attention Deficit Hyperactivity Disorder (ADHD) may play a role in initiation and heightened use over time. The purpose of this application is to elucidate the link between ADHD symptoms and etiology of tobacco and alcohol use. The main innovation is the application of advanced analytic methods for characterizing ADHD phenotypes and characterizing developmental trajectories of tobacco use, alcohol use and tobacco-alcohol joint probability using two large nationally representative databases. The successful completion of this proposal will result in refined knowledge concerning the influence of ADHD symptoms on substance use from adolescence to young adulthood. Such knowledge is necessary for effective preventive intervention planning and implementation.
|Clark, Trenette T; Yang, Chongming; McClernon, F Joseph et al. (2015) Racial differences in parenting style typologies and heavy episodic drinking trajectories. Health Psychol 34:697-708|
|Fuemmeler, Bernard; Lee, Chien-Ti; Ranby, Krista W et al. (2013) Individual- and community-level correlates of cigarette-smoking trajectories from age 13 to 32 in a U.S. population-based sample. Drug Alcohol Depend 132:301-8|
|Clark, Trenette T; Corneille, Maya; Coman, Emanuel (2013) Developmental trajectories of alcohol use among monoracial and biracial Black adolescents and adults. J Psychoactive Drugs 45:249-57|
|Lee, Chien-Ti; McClernon, F Joseph; Kollins, Scott H et al. (2013) Childhood economic strains in predicting substance use in emerging adulthood: mediation effects of youth self-control and parenting practices. J Pediatr Psychol 38:1130-43|
|Lee, Chien-Ti; Fuemmeler, Bernard F; McClernon, F Joseph et al. (2013) Nicotinic receptor gene variants interact with attention deficient hyperactive disorder symptoms to predict smoking trajectories from early adolescence to adulthood. Addict Behav 38:2683-9|
|Bidwell, L Cinnamon; Garrett, Melanie E; McClernon, F Joseph et al. (2012) A preliminary analysis of interactions between genotype, retrospective ADHD symptoms, and initial reactions to smoking in a sample of young adults. Nicotine Tob Res 14:229-33|
|Ranby, Krista W; Boynton, Marcella H; Kollins, Scott H et al. (2012) Understanding the phenotypic structure of adult retrospective ADHD symptoms during childhood in the United States. J Clin Child Adolesc Psychol 41:261-74|