. More people in the United States are addicted to cannabis than to any other illicit drug, and prevalence of its use is rising, accompanied by a decline in its perceived harm among adolescents. Important maturational changes in prefrontal cortex during adolescence may make youth more vulnerable than adults to adverse effects from cannabis. Indeed, research shows impairments in memory performance and decision-making abilities of heavy cannabis users, most of whom initiate use during adolescence. However, little is known about how decision-making and memory are affected across the trajectory from initial experimentation to development of cannabis addiction. Furthermore, there is controversy in the scientific literature on whether the impairments in decision-making observed among heavy cannabis users are due to the harmful effects of cannabis on brain functioning, or whether they may be an antecedent risk factor for the development of cannabis addiction. The principal goals of this proposal are to determine whether: a) decision-making is an antecedent risk factor for cannabis addiction; and b) what changes occur in decision-making and episodic memory along different cannabis use trajectories. Participants will be 480 youth ages 14 to 15 at baseline, most of whom will have experimented with cannabis, but have yet to develop addiction. Over three years, their performance will be assessed on measures of decision-making and episodic memory every 18 months and on their substance use and symptoms of cannabis addiction every 9 months. Poorer decision-making at baseline is hypothesized to be associated with increased risk of developing cannabis addiction during follow-up. Similarly, declines in decision- making during follow-up are hypothesized to be associated with increased severity of cannabis addiction (i.e., more compulsive use and more negative consequences). Finally, those who escalate in their cannabis consumption over time will show greater deterioration in their episodic memory than observed in other (non-escalating or desisting) cannabis use trajectories. In contrast, decision-making will show little change across all trajectories, consistent with its hypothesized role as an antecedent, rather than a consequence, of cannabis addiction. Understanding more about the links between neuropsychological functions and cannabis addiction will help clarify theoretical models pertaining to their temporal association. Clinically, knowing more about neuropsychological predictors and sequelae of addiction will help us to develop more targeted and tailored interventions and prevention programs, consistent with NIDA's goals. Importantly, our findings will clarify whether decision-making is an antecedent risk factor for cannabis use and addiction, a consequence of use, or both.
. Prevalence of marijuana use is escalating among adolescents, along with declines in perceptions of risk with use. People who use marijuana sometimes show impairments in their memory and decision-making abilities. This study will help to determine if problems with decision-making are one of the reasons that some teens become addicted to marijuana. It will also describe how progressing from experimental marijuana use to addiction affects memory and decision-making. Knowing more about predictors of marijuana addiction will help us to develop specific interventions and prevention programs for teens.
|Vidot, Denise C; Lerner, Brenda; Gonzalez, Raul (2017) Cannabis Use, Medication Management and Adherence Among Persons Living with HIV. AIDS Behav 21:2005-2013|
|Ross, J Megan; Graziano, Paulo; Pacheco-Colón, Ileana et al. (2016) Decision-Making Does not Moderate the Association between Cannabis Use and Body Mass Index among Adolescent Cannabis Users. J Int Neuropsychol Soc 22:944-949|
|Ross, J Megan; Duperrouzel, Jacqueline; Vega, Melanie et al. (2016) The Neuropsychology of Risky Sexual Behavior. J Int Neuropsychol Soc 22:586-94|
|Ross, J Megan; Coxe, Stefany; Schuster, Randi M et al. (2015) The moderating effects of cannabis use and decision making on the relationship between conduct disorder and risky sexual behavior. J Clin Exp Neuropsychol 37:303-15|
|Gonzalez, Raul; Schuster, Randi M; Mermelstein, Robin M et al. (2015) The role of decision-making in cannabis-related problems among young adults. Drug Alcohol Depend 154:214-21|
|Crane, Natania A; Schuster, Randi Melissa; Mermelstein, Robin J et al. (2015) Neuropsychological sex differences associated with age of initiated use among young adult cannabis users. J Clin Exp Neuropsychol 37:389-401|
|Schuster, Randi M; Crane, Natania A; Mermelstein, Robin et al. (2015) Tobacco may mask poorer episodic memory among young adult cannabis users. Neuropsychology 29:759-66|
|Crane, Natania A; Schuster, Randi Melissa; Fusar-Poli, Paolo et al. (2013) Effects of cannabis on neurocognitive functioning: recent advances, neurodevelopmental influences, and sex differences. Neuropsychol Rev 23:117-37|
|Crane, Natania A; Schuster, Randi Melissa; Gonzalez, Raul (2013) Preliminary evidence for a sex-specific relationship between amount of cannabis use and neurocognitive performance in young adult cannabis users. J Int Neuropsychol Soc 19:1009-15|
|Gonzalez, Raul; Schuster, Randi Melissa; Mermelstein, Robin J et al. (2012) Performance of young adult cannabis users on neurocognitive measures of impulsive behavior and their relationship to symptoms of cannabis use disorders. J Clin Exp Neuropsychol 34:962-76|