This proposal, submitted by an early stage investigator, seeks four years of R01 support to conduct an MRI study of adolescent patients with serious substance and conduct problems and adolescent controls. This proposal seeks to identify the neural correlates (both functional and structural) of callous-unemotionality (CU). CU is identifiable in childhood and adolescence, is a relatively stable trait into adulthood, and is linked with persistent antisocial behavior problems and substance dependence;individuals with CU, antisocial behavior problems and substance use disorders appear more resistant to treatment. This proposal will also allow searching for neural correlates of subtypes of adolescent-onset substance dependence. We will recruit, complete extensive diagnostic interviews and image subjects while they play the AlAn's game. That game, which was designed for use in the MRI environment, has demonstrated a strong relationship with CU trait scores in our out-of-magnet pilot testing.

Public Health Relevance

Substance use disorders and antisocial behavior are major public health problems, are linked to serious morbidity and high mortality and have a partial genetic etiology. Callous-unemotional traits are identifiable in childhood and adolescents, are relatively stable into young adulthood and predict future and persistent antisocial behavior and substance problems. The current study proposes a search for neurobiological correlates callous-unemotionality and subtypes of adolescent-onset substance dependence. Better understanding the biological etiology of these disorders may lead to better prevention or treatment approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA031761-03
Application #
8623120
Study Section
Child Psychopathology and Developmental Disabilities Study Section (CPDD)
Program Officer
Boyce, Cheryl A
Project Start
2012-04-15
Project End
2016-02-28
Budget Start
2014-03-01
Budget End
2015-02-28
Support Year
3
Fiscal Year
2014
Total Cost
$348,282
Indirect Cost
$123,282
Name
University of Colorado Denver
Department
Psychiatry
Type
Schools of Medicine
DUNS #
041096314
City
Aurora
State
CO
Country
United States
Zip Code
80045
Sakai, Joseph T; Dalwani, Manish S; Mikulich-Gilbertson, Susan K et al. (2017) Imaging decision about whether to benefit self by harming others: Adolescents with conduct and substance problems, with or without callous-unemotionality, or developing typically. Psychiatry Res 263:103-112
Crowley, Thomas J; Dalwani, Manish S; Sakai, Joseph T et al. (2017) Children's brain activation during risky decision-making: A contributor to substance problems? Drug Alcohol Depend 178:57-65
Yamamoto, Dorothy J; Banich, Marie T; Regner, Michael F et al. (2017) Behavioral approach and orbitofrontal cortical activity during decision-making in substance dependence. Drug Alcohol Depend 180:234-240
Sakai, Joseph T; Dalwani, Manish S; Mikulich-Gilbertson, Susan K et al. (2016) A Behavioral Measure of Costly Helping: Replicating and Extending the Association with Callous Unemotional Traits in Male Adolescents. PLoS One 11:e0151678
Coors, Marilyn E; Raymond, Kristen M; Hopfer, Christian J et al. (2016) Adolescents with substance use disorder and assent/consent: Empirical data on understanding biobank risks in genomic research. Drug Alcohol Depend 159:267-71
Boulos, Peter K; Dalwani, Manish S; Tanabe, Jody et al. (2016) Brain Cortical Thickness Differences in Adolescent Females with Substance Use Disorders. PLoS One 11:e0152983
Sakai, Joseph T; Mikulich-Gilbertson, Susan K; Young, Susan E et al. (2016) Adolescent Male Conduct-Disordered Patients in Substance Use Disorder Treatment: Examining the ""Limited Prosocial Emotions"" Specifier. J Child Adolesc Subst Abuse 25:613-625
Dalwani, Manish S; McMahon, Mary Agnes; Mikulich-Gilbertson, Susan K et al. (2015) Female adolescents with severe substance and conduct problems have substantially less brain gray matter volume. PLoS One 10:e0126368
Crowley, Thomas J; Dalwani, Manish S; Mikulich-Gilbertson, Susan K et al. (2015) Adolescents' Neural Processing of Risky Decisions: Effects of Sex and Behavioral Disinhibition. PLoS One 10:e0132322
Chumachenko, Serhiy Y; Sakai, Joseph T; Dalwani, Manish S et al. (2015) Brain cortical thickness in male adolescents with serious substance use and conduct problems. Am J Drug Alcohol Abuse :1-11

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