India is home to the third largest population of HIV-infected persons globally and also to ~ 1.1 million injection drug users (IDUs). Data from our group and others show poor penetrance of voluntary counseling and testing (VCT) and risk-reduction services among IDUs, as well as late HIV diagnosis, poor uptake of antiretroviral therapy (ART), and high mortality among HIV-infected IDUs. A multi-level strategy - which facilitates access through an integrated structural intervention, disseminates the intervention by leveraging social networks, and addresses individual barriers (e.g., substance abuse, comorbidities) - is needed to improve HIV prevention and treatment among IDUs. Prior work from our group and others suggests that integrated models of care can improve outcomes in populations with comorbid substance abuse and medical conditions. We propose that IDU-oriented integrated care clinics (ICCs) can engage vulnerable IDU populations and improve community-level outcomes along the """"""""seek, test, treat and retain"""""""" (STTR) continuum.
Aim 1 : Determine HIV prevalence and characterize access to preventive and treatment services among IDUs in 15 geographically distinct communities in India using ethnographic approaches and respondent-driven sampling (RDS). RDS is a chain-referral sampling method that is implemented in a manner that enables unbiased prevalence estimates of selected factors in the target population. We will use this information methodologically and analytically in Aim 2.
Aim 2 : Evaluate the effectiveness of IDU-oriented integrated care clinics (ICCs) for improving outcomes along the """"""""seek, test, treat, and retain"""""""" (STTR) continuum using a cluster-randomized trial. We will conduct a cluster-randomized trial among 5 pairs of matched communities (10 communities total) selected from the 15 candidate communities assessed in Aim 1. Communities will be matched according to geographic region and proportion reporting VCT in the prior 12 months at baseline. Starting with existing IDU-oriented service providers, we will establish ICCs in the 5 intervention communities. ICCs will provide the 9 IDU services recommended in the World Health Organization (WHO) 'comprehensive package': HIV VCT;condom distribution;counseling and education;needle exchange programs;opioid substitution therapy;management of sexually transmitted infections, tuberculosis, and viral hepatitis;and ART. Community-level outcomes will be assessed with a second (evaluation) RDS conducted 24 months after ICC implementation. We hypothesize that establishing IDU-oriented ICCs will lead to increased access to VCT, reduced HIV transmission risk behaviors, and (among HIV-infected persons) increased access to clinical care, increased use of ART, and decreased community viral load. While our proposed study will be conducted in India, its results may be applicable to IDU-prevalent areas worldwide as fragmented delivery of these services is the norm in both developed and developing countries.

Public Health Relevance

Injection drug users often have poor access to HIV prevention services and HIV treatment. In this project, we propose to test whether establishing integrated care clinics that are oriented to injection drug users can improve HIV prevention and treatment outcomes in this vulnerable population. While this project will be conducted in India, it is relevant and potentially applicable to areas in both the developing and developed world where injection drug use is an important mode of HIV transmission.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA032059-03
Application #
8452133
Study Section
Special Emphasis Panel (ZDA1-NXR-B (06))
Program Officer
Jones, Dionne
Project Start
2011-07-15
Project End
2016-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
3
Fiscal Year
2013
Total Cost
$1,302,274
Indirect Cost
$105,917
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
001910777
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Smith, M K; Graham, M; Latkin, C A et al. (2018) Quantifying potentially infectious sharing patterns among people who inject drugs in Baltimore, USA. Epidemiol Infect 146:1845-1853
Solomon, Sunil S; McFall, Allison M; Lucas, Gregory M et al. (2017) Respondent-driven sampling for identification of HIV- and HCV-infected people who inject drugs and men who have sex with men in India: A cross-sectional, community-based analysis. PLoS Med 14:e1002460
Sabri, Bushra; McFall, Allison M; Solomon, Sunil S et al. (2017) Gender Differences in Factors Related to HIV Risk Behaviors among People Who Inject Drugs in North-East India. PLoS One 12:e0169482
Chandler, Redonna; Gordon, Michael S; Kruszka, Bridget et al. (2017) Cohort profile: seek, test, treat and retain United States criminal justice cohort. Subst Abuse Treat Prev Policy 12:24
Cepeda, Javier A; Solomon, Sunil S; Srikrishnan, Aylur K et al. (2017) Injection Drug Network Characteristics Are Important Markers of HIV Risk Behavior and Lack of Viral Suppression. J Acquir Immune Defic Syndr 75:257-264
Nance, Robin M; Delaney, J A Chris; Golin, Carol E et al. (2017) Co-calibration of two self-reported measures of adherence to antiretroviral therapy. AIDS Care 29:464-468
McFall, Allison M; Solomon, Sunil S; Lucas, Greg M et al. (2017) Epidemiology of HIV and hepatitis C infection among women who inject drugs in Northeast India: a respondent-driven sampling study. Addiction 112:1480-1487
Solomon, Sunil S; Lucas, Gregory M; Celentano, David D et al. (2016) Design of the Indian NCA study (Indian national collaboration on AIDS): a cluster randomized trial to evaluate the effectiveness of integrated care centers to improve HIV outcomes among men who have sex with men and persons who inject drugs in India. BMC Health Serv Res 16:652
McFall, Allison M; Mehta, Shruti H; Srikrishnan, Aylur K et al. (2016) Getting to 90: linkage to HIV care among men who have sex with men and people who inject drugs in India. AIDS Care 28:1230-9
Solomon, Sunil Suhas; Mehta, Shruti H; McFall, Allison M et al. (2016) Community viral load, antiretroviral therapy coverage, and HIV incidence in India: a cross-sectional, comparative study. Lancet HIV 3:e183-90

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