Substance abuse is a major public health problem that is on the rise among adolescent girls. Despite this, we know relatively little about what risk factors lead to substance use and abuse in girls. One important risk factor that is significant for girls and that show changes in adolescence is the family environment. Previous research indicates that a family history of addiction and poor reported parenting are linked to youth's substance use, particularly for girls. However, how poor global parenting leads to substance abuse risk is not known. In addition, although talking with children about drug use is widely recommended to parents, the specific parental advice about drug use that is most effective is not known. The proposed study will address this knowledge gap by using an innovative, newly developed, and validated laboratory paradigm to assess observed parenting behaviors and adolescent multi-modal emotional and physiological responses to parent- adolescent conflict and drug use discussion interactions as these predict increases in adolescent substance use from early to middle adolescence. We hypothesize that observed parenting behaviors in the conflict and drug use discussion interactions (e.g., low warmth, high criticism, avoidance of drug discussion) and heightened adolescent emotional and physiological responses will predict initiation of and increases in substance use/abuse over time and that this prediction will be stronger for girls than boys. We will observe parent-adolescent interactions in a representative community sample of 240 12-13 year old girls and boys. In a laboratory session, parent-adolescent pairs will discuss a personalized conflict topic and the topic of drug use. Parenting behaviors (warmth, structuring, and criticism) and content of drug use discussions (avoiding drug discussion, discussing rules, examples, and consequences of drug use) and contingent emotion and heart rate will be coded continuously using a novel micro-analytic coding system. Before and at repeated time-points during and after the interaction, adolescents'and parents'emotional, physiological (heart rate, blood pressure), and neuroendocrine (cortisol) arousal will be assessed. Youth will complete biological, self-report, and clinical interview measures of substance use and abuse and associated behavior problems and depressive symptoms at Time 1 and at 6 month, and 1, 2, and 3 year follow ups. Parents will complete clinical interviews of their substance abuse and stress. Hypotheses will be tested with sophisticated longitudinal modeling techniques including Hierarchical Linear Modeling (HLM). If the hypotheses are supported, the proposed study will isolate targets for gender-based prevention programs, addressing NIDA's mission of identifying risk factors to improve intervention efficacy. Family-based preventions could identify girls with high responses to brief family talks and could target specific parenting behaviors and parent drug use advice that reduces youth arousal and substance use. Through this work we hope to discover novel, gender-sensitive, prevention strategies.

Public Health Relevance

Adolescence is a period of high risk for the development of substance use disorders (SUDs), but how risk factors such as family environment contribute to increases in SUDs, especially increasing SUD rates for girls, is not clear. The proposed research will examine gender-related multi-modal responses to parent-adolescent conflict and drug use discussions and explore the bio-behavioral mechanisms underlying the well-known impact of parenting and family factors on the development of SUDs in youth. Findings from this research will help improve family-based substance abuse prevention programs for adolescent girls and boys.

National Institute of Health (NIH)
National Institute on Drug Abuse (NIDA)
Research Project (R01)
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Risk, Prevention and Intervention for Addictions Study Section (RPIA)
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Boyce, Cheryl A
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George Mason University
Schools of Arts and Sciences
United States
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Panjwani, Naaila; Chaplin, Tara M; Sinha, Rajita et al. (2016) Gender Differences in Emotion Expression in Low-Income Adolescents Under Stress. J Nonverbal Behav 40:117-132
Poon, Jennifer A; Turpyn, Caitlin C; Hansen, Amysue et al. (2016) Adolescent Substance Use & Psychopathology: Interactive Effects of Cortisol Reactivity and Emotion Regulation. Cognit Ther Res 40:368-380
Turpyn, Caitlin C; Chaplin, Tara M (2016) Mindful Parenting and Parents' Emotion Expression: Effects on Adolescent Risk Behaviors. Mindfulness (N Y) 7:246-254
Turpyn, Caitlin C; Chaplin, Tara M; Cook, Emily C et al. (2015) A person-centered approach to adolescent emotion regulation: Associations with psychopathology and parenting. J Exp Child Psychol 136:1-16
Cook, Emily C; Chaplin, Tara M; Stroud, Laura R (2015) The Relationship Between Autonomy and Relatedness and Adolescents' Adrenocortical and Cardiovascular Stress Response. J Youth Adolesc 44:1999-2011
Chaplin, Tara M (2015) Gender and Emotion Expression: A Developmental Contextual Perspective. Emot Rev 7:14-21
Chaplin, Tara M; Visconti, Kari Jeanne; Molfese, Peter J et al. (2015) Prenatal cocaine exposure differentially affects stress responses in girls and boys: associations with future substance use. Dev Psychopathol 27:163-80
Chaplin, Tara M; Hansen, Amysue; Simmons, Jessica et al. (2014) Parental-adolescent drug use discussions: physiological responses and associated outcomes. J Adolesc Health 55:730-5
Rando, Kenneth; Chaplin, Tara M; Potenza, Marc N et al. (2013) Prenatal cocaine exposure and gray matter volume in adolescent boys and girls: relationship to substance use initiation. Biol Psychiatry 74:482-9
Chaplin, Tara M; Aldao, Amelia (2013) Gender differences in emotion expression in children: a meta-analytic review. Psychol Bull 139:735-65

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