Marijuana is the most commonly used and abused illicit drug in the U.S. The prevalence of marijuana use (MU) increases across adolescence, peaks in the early 20s, and gradually declines thereafter. However, there is considerable individual variability in developmental trajectories of MU, with some adolescents continuing to use marijuana into early adulthood and others desisting from MU over time. While several studies have examined factors that predict MU during adolescence, little is known about the processes that promote or hinder desistance from MU into adulthood. Additionally, few studies have characterized the adverse adult outcomes associated with divergent trajectories of MU, including potential impairments in brain structure and function that may result from frequent use in adolescence. Moreover, most studies on teen MU have focused on predominately White samples, making it unclear whether the findings can be extrapolated to Black teens. This proposal will address these limitations by leveraging data from the Pittsburgh Youth Study (PYS), a prospective longitudinal study that includes 1009 boys in two cohorts followed from childhood (age 6) or early adolescence (age 12) into young adulthood (age 28 or 35).
The aims are to: 1) Characterize the developmental course of MU from adolescence to adulthood and examine the risk/protective factors and early adult positive life events that influence MU in Black and White males;2) Document the link between different developmental trajectories of MU and adult psychosocial adjustment in Black and White males;and 3) Examine the association between frequent adolescent MU and abnormalities in brain structure and function in adulthood. State-of-the-art analysis will identify varying trajectories of MU from early adolescence to adulthood. Path analysis will assess the processes by which early antisocial risk and pro social protective factors influence trajectories of MU, and determine whether positive adult life events influence deviations from ongoing MU trajectories. The adverse adult psychosocial outcomes associated with developmental patterns of MU will also be delineated. Across these analyses, we will explore potential differences in the patterns, precursors, and outcomes associated with MU in Black males relative to Whites, including examining what factors may help explain racial differences in MU. Finally, using a subsample of PYS youth who participated in a neuroimaging study (N=171), we will determine whether frequent adolescent MU is associated with gray and white matter brain abnormalities in adulthood, and brain function deficits while processing emotional cues and receiving rewards. The pioneering papers generated from this project will help to identify developmentally salient and culturally appropriate risk/protective factors that should be targeted by programs designed to prevent chronic MU. They will also elucidate the potential negative psychosocial and neurobiological consequences associated with different trajectories of MU, which can be incorporated into motivational enhancement interventions for marijuana using teens and inform public policies regarding the legalization of marijuana for medical use.
The prevalence of marijuana use among teenagers in the U.S. has increased in recent years, while teen alcohol and tobacco use have reached historic lows. This study is designed to examine the early risk and protective factors that influence the development of marijuana use from adolescence into adulthood to help identify youth in need of targeted prevention efforts. In addition, the proposed project will elucidate the potential adverse impact that frequent adolescent marijuana use may have on psychosocial adjustment and brain structure/function in young adulthood.
|CerdÃ¡, Magdalena; Prins, Seth J; Galea, Sandro et al. (2016) When psychopathology matters most: identifying sensitive periods when within-person changes in conduct, affective and anxiety problems are associated with male adolescent substance use. Addiction 111:924-35|
|Bechtold, Jordan; Hipwell, Alison; Lewis, David A et al. (2016) Concurrent and Sustained Cumulative Effects of Adolescent Marijuana Use on Subclinical Psychotic Symptoms. Am J Psychiatry 173:781-9|
|Pardini, Dustin; Bechtold, Jordan; Loeber, Rolf et al. (2015) Developmental Trajectories of Marijuana Use among Men: Examining Linkages with Criminal Behavior and Psychopathic Features into the Mid-30s. J Res Crime Delinq 52:797-828|
|White, Helene R; Buckman, Jennifer; Pardini, Dustin et al. (2015) The Association of Alcohol and Drug Use with Persistence of Violent Offending in Young Adulthood. J Dev Life Course Criminol 1:289-303|
|White, Helene R; Bechtold, Jordan; Loeber, Rolf et al. (2015) Divergent marijuana trajectories among men: Socioeconomic, relationship, and life satisfaction outcomes in the mid-30s. Drug Alcohol Depend 156:62-9|
|Pardini, Dustin; White, Helene R; Xiong, Shuangyan et al. (2015) Unfazed or Dazed and Confused: Does Early Adolescent Marijuana Use Cause Sustained Impairments in Attention and Academic Functioning? J Abnorm Child Psychol 43:1203-17|
|Colins, Olivier F; Andershed, Henrik; Pardini, Dustin A (2015) Psychopathic traits as predictors of future criminality, intimate partner aggression, and substance use in young adult men. Law Hum Behav 39:547-58|
|White, Helene R; Jiao, Yang; Ray, Anne E et al. (2015) Are there secondary effects on marijuana use from brief alcohol interventions for college students? J Stud Alcohol Drugs 76:367-77|
|Bjork, James M; Pardini, Dustin A (2015) Who are those ""risk-taking adolescents""? Individual differences in developmental neuroimaging research. Dev Cogn Neurosci 11:56-64|
|Bechtold, Jordan; Simpson, Theresa; White, Helene R et al. (2015) Chronic adolescent marijuana use as a risk factor for physical and mental health problems in young adult men. Psychol Addict Behav 29:552-63|
Showing the most recent 10 out of 12 publications