Men who have sex with men (MSM) are the largest HIV transmission group in the US and infections are increasing most among young MSM (18-24 years), however, few HIV prevention programs have been developed and proven effective with this vulnerable population. To address these HIV prevention concerns, we collaborated with community-based organizations (CBOs) in the context of an NIH R34 grant to develop and pilot test, Keep It Up! (KIU!), an online HIV prevention program tailored to ethnically diverse YMSM. KIU! is based on the Information-Motivation-Behavior Skills (IMB) model of HIV risk behavior change and informed by principals of E-learning. Our small-scale pilot randomized clinical trial (RCT) demonstrated the feasibility and acceptability of the KIU! intervention: we enrolled an ethnically diverse sample of YMSM;achieved excellent retention through 3-month follow-up (89%);maintained robust intervention engagement;and produced a significant 44% decrease in unprotected anal sex relative to an active control. The overarching goal of the current proposal is to advance scientific knowledge of technology-based, behavioral HIV prevention, as well as improve public health by establishing the efficacy of an innovative eHealth prevention program for YMSM. We will accomplish these goals with three specific aims. First, we will integrate the KIU! intervention into a widely-used health technology platform to increase its scalability, adaptability, and potential for broad implementation. Second, we will test the efficacy of the KIU! eHealth intervention in a multisite RCT by: a) enrolling ethnically diverse YMSM (N = 750;>65% racial/ethnic minorities) who tested HIV negative in the clinics of our community partners in Chicago and New York;b) randomizing participants to either the KIU! intervention or an HIV knowledge control condition;and c) measuring intervention outcomes at baseline and follow-up assessments at 3, 6, and 12 months. The primary behavioral outcome will be the count of unprotected anal sex acts and the primary biomedical outcome will be STI incidence. And third, we will explore if the KIU! intervention has differential efficacy across important sub-groups of YMSM based on race/ethnicity, relationship status (serious versus casual relationships), and gay/bisexual identity. Our KIU! approach is innovative in linking an eHealth solution to HIV and STI testing, as well as serving as model for integrating scalable behavioral prevention into other biomedical prevention strategies.

Public Health Relevance

Men who have sex with men (MSM) are the largest HIV transmission group in the US and infections are increasing most among young MSM (18-24 years), however, few HIV prevention programs have been developed and proven effective with this vulnerable population. The overarching goal of this proposal is to improve public health by establishing the efficacy of an innovative, Internet-based HIV prevention program for YMSM.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
5R01DA035145-03
Application #
8711422
Study Section
Special Emphasis Panel (ZRG1)
Program Officer
Jenkins, Richard A
Project Start
2012-09-01
Project End
2017-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
3
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60611
Feinstein, Brian A; Dellucci, Trey V; Graham, Simon et al. (2018) Sexually transmitted infections among young men who have sex with men: Experiences with diagnosis, treatment, and reinfection. Sex Res Social Policy 15:172-182
Feinstein, Brian A; Dellucci, Trey V; Sullivan, Patrick S et al. (2018) Characterizing Sexual Agreements With One's Most Recent Sexual Partner Among Young Men Who Have Sex With Men. AIDS Educ Prev 30:335-349
Ventuneac, Ana; John, Steven A; Whitfield, Thomas H F et al. (2018) Preferences for Sexual Health Smartphone App Features Among Gay and Bisexual Men. AIDS Behav 22:3384-3394
Madkins, Krystal; Greene, George J; Hall, Eric et al. (2018) Attrition and HIV Risk Behaviors: A Comparison of Young Men Who Have Sex with Men Recruited from Online and Offline Venues for an Online HIV Prevention Program. Arch Sex Behav 47:2135-2148
Mustanski, Brian; Parsons, Jeffrey T; Sullivan, Patrick S et al. (2018) Biomedical and Behavioral Outcomes of Keep It Up!: An eHealth HIV Prevention Program RCT. Am J Prev Med 55:151-158
Feinstein, Brian A; Moody, Raymond L; John, Steven A et al. (2018) A three-city comparison of drug use and drug use before sex among young men who have sex with men in the United States. J Gay Lesbian Soc Serv 30:82-101
Janulis, Patrick; Newcomb, Michael E; Sullivan, Patrick et al. (2018) Evaluating HIV Knowledge Questionnaires Among Men Who Have Sex with Men: A Multi-Study Item Response Theory Analysis. Arch Sex Behav 47:107-119
Mustanski, Brian; Feinstein, Brian A; Madkins, Krystal et al. (2017) Prevalence and Risk Factors for Rectal and Urethral Sexually Transmitted Infections From Self-Collected Samples Among Young Men Who Have Sex With Men Participating in the Keep It Up! 2.0 Randomized Controlled Trial. Sex Transm Dis 44:483-488
Strauss, Benjamin B; Greene, George J; Phillips 2nd, Gregory et al. (2017) Exploring Patterns of Awareness and Use of HIV Pre-Exposure Prophylaxis Among Young Men Who Have Sex with Men. AIDS Behav 21:1288-1298
Motley, Darnell N; Hammond, Sydney; Mustanski, Brian (2017) Strategies Chosen by YMSM During Goal Setting to Reduce Risk for HIV and Other Sexually Transmitted Infections: Results From the Keep It Up! 2.0 Prevention Trial. AIDS Educ Prev 29:1-13

Showing the most recent 10 out of 21 publications