There are 1.1 million persons living with HIV (PLWH) in the US, 60% of them smoke cigarettes, and 75% of these are interested in quitting. Almost none are currently accessing smoking cessation interventions designed to meet their specific needs and concerns. Cigarette smoking is responsible for 24% of deaths among PLWH, and 30% of non-AIDS defining malignancies. It is driving the alarming rise in cardiac events and lung cancers in this highly vulnerable population. The lack of access to proven, effective, culturally appropriate tobacco cessation services represents a health disparity of the first order. The psychosocial profile of the PLWH-smoker community, characterized by high rates of psychiatric comorbidity, drug and alcohol use, and low levels of social support, suggests that achieving high cessation rates will be a great challenge. Positively Smoke Free (PSF) is an intensive, multisession, group cessation program specifically developed for PLWH smokers. A pilot study of PSF yielded promising results. This proposal aims (1) to perform a definitive efficacy study of PSF by comparing 6-month biochemically confirmed abstinence rates in subjects randomized to PSF vs. standard care in a cohort of 450 PLWH smokers, (2) to determine the sociobehavioral moderators and mediators associated with successful cessation, and (3) to complete a careful cost analysis of PSF in order to estimate the incremental cost per quit associated program participation. If PSF is proven to be effective it will establish a new treatment option for PLWH smokers. Determination of moderators and mediators of program success will provide insight into the mode of action of the intervention and will help guide the development of additional treatment strategies in the future. Finally, the cost analyses will provide critical information abut the feasibility of program dissemination and implementation.

Public Health Relevance

The epidemic of cigarette smoking is fueling an alarming rise in lung and other cancers in persons living with HIV (PLWH). Smokers living with HIV have few, if any, cessation resources available to them that address their particular needs, and HIV care providers have virtually no evidence base to guide their approach to tobacco treatment. The proposal, if funded, will conduct a definitive study of a group therapy intervention for PLWH smokers that showed promise in a pilot trial.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
6R01DA036445-04
Application #
9184873
Study Section
Special Emphasis Panel (ZRG1-AARR-F (02))
Program Officer
Kahana, Shoshana Y
Project Start
2013-08-01
Project End
2018-07-31
Budget Start
2015-09-01
Budget End
2016-07-31
Support Year
4
Fiscal Year
2015
Total Cost
$676,287
Indirect Cost
$203,393
Name
Albert Einstein College of Medicine, Inc
Department
Type
DUNS #
079783367
City
Bronx
State
NY
Country
United States
Zip Code
10461
Kim, Ryung S; Weinberger, Andrea H; Chander, Geetanjali et al. (2018) Cigarette Smoking in Persons Living with Hepatitis C: The National Health and Nutrition Examination Survey (NHANES), 1999-2014. Am J Med 131:669-675
Weinberger, Andrea H; Seng, Elizabeth K; Esan, Hannah et al. (2018) Perceived risks and benefits of quitting smoking in a sample of adults living with HIV/AIDS. AIDS Care 30:564-568
Marhefka, Stephanie L; Turner, DeAnne; Lockhart, Elizabeth et al. (2018) Meeting Our Patients ""Where They Are"": Video-Group Smoking Cessation for People Living With HIV. J Assoc Nurses AIDS Care 29:338-344
Weinberger, Andrea H; Smith, Philip H; Funk, Allison P et al. (2017) Sex Differences in Tobacco Use Among Persons Living With HIV/AIDS: A Systematic Review and Meta-Analysis. J Acquir Immune Defic Syndr 74:439-453