Veterans returning home from recent engagements in Iraq and Afghanistan represent a vulnerable population at disproportionate risk of prescription opioid (PO) misuse and overdose. As current research is demonstrating, these risks are potentially even higher for women, minority, homeless, and otherwise socially isolated veterans, as well as those with mental health concerns. Despite these preliminary findings about the clustering of opioid- related risks among particular veteran subpopulations, very little is currenty known about how these risks emerge over time and what conditions and events precipitate them. This project represents one of the first to address the emergence of opioid-related risk behaviors over time and to track the changing dimensions of veterans'reintegration experiences that impact PO and other substance use patterns. Accordingly, this study will track opioid-using veterans'substance use patterns alongside other physiological, psychological, and social dimensions of their lives, ranging from post-traumatic stress disorder (PTSD) symptoms, depression, and pain severity to social relationships and employment status. The study will provide critical insights into the stressors, turning points, and substance use patterns that precede emergence of overdose risk behaviors and the protective factors that keep some opioid-using veterans safe despite their struggles with pain and the psychosocial challenges of reintegration. To do so, it will investigate the following aims:
Aim A: Identify key contextual dimensions of opioid-related overdose risk among veterans. Qualitative interviews will be administered to 50 recent veterans who have received prescription opioids for pain and who have experienced at least one non-fatal overdose involving opioids. The data obtained will illuminate the relationships among pain, opioid medications, mental health concerns, life stressors, and overdose risk. These data will inform instrument design and refinement for Aims B and C.
Aim B: Identify biological, psychological and social factors related to veterans'transitions into and out of overdose risk over time. The project will survey 250 PO-using recent veterans and follow them for two years, collecting monthly data using interactive voice response (IVR) technology in order to: 1) Develop an Overdose Risk Behavior Scale (ORBS) based on the literature, existing scales for aberrant PO use, known overdose risks, and common risks among veterans (especially as identified in Aim A);and 2) Test hypotheses regarding potential biopsychosocial (BPS) correlates of overdose risk behavior.
Aim C: Identify veterans'subjective perceptions of changes in overdose risk over time and how these contribute to the mechanisms underlying changes in opioid use patterns. Ongoing qualitative interviews with an embedded subsample of 32 veterans will provide an important supplement to the findings from Aim B, revealing veterans'subjective perceptions, understandings and misunderstandings that accompany changes in pain, mental health and social support, thus providing a foundation underlying changes in overdose risk.

Public Health Relevance

This study promises to greatly inform efforts to identify effective programs for preventing opioid misuse and opioid-related overdose among veterans. Identification of the salient contexts for risky opioid use and an understanding of how even routine, adherent pain management behaviors can evolve into risky ones will provide the means to more creative and time-sensitive interventions to prevent or mitigate risky behaviors before they lead to negative health consequences including overdose and even untimely death. Similarly, understanding how veterans themselves conceptualize risk, and draw on social and institutional supports, will allow for greater refinement in future efforts to educate veterans and assist them in establishing meaningful institutional affiliations and social relationships that may serve as protective factors against opioid-related health risks.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Project (R01)
Project #
1R01DA036754-01A1
Application #
8728474
Study Section
Risk, Prevention and Intervention for Addictions Study Section (RPIA)
Program Officer
Schulden, Jeffrey D
Project Start
2014-04-01
Project End
2018-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
1
Fiscal Year
2014
Total Cost
$422,871
Indirect Cost
$147,385
Name
National Development & Research Institutes
Department
Type
DUNS #
080481880
City
New York
State
NY
Country
United States
Zip Code
10010
Wolfson-Stofko, Brett; Elliott, Luther; Bennett, Alex S et al. (2018) Perspectives on supervised injection facilities among service industry employees in New York City: A qualitative exploration. Int J Drug Policy 62:67-73
Wolfson-Stofko, Brett; Gwadz, Marya V; Elliott, Luther et al. (2018) ""Feeling confident and equipped"": Evaluating the acceptability and efficacy of an overdose response and naloxone administration intervention to service industry employees in New York City. Drug Alcohol Depend 192:362-370
Elliott, Luther; Bennett, Alexander S; Szott, Kelly et al. (2018) Competing Constructivisms: The Negotiation of PTSD and Related Stigma Among Post-9/11 Veterans in New York City. Cult Med Psychiatry 42:778-799
Elliott, Luther; Golub, Andrew; Bennett, Alexander (2018) Opioid Use Initiation, Progression, and Motivations Among OEF/OIF/OND-Era Veterans in New York City: An Age-Period-Cohort Analysis. Mil Behav Health 6:75-81
Pouget, Enrique R; Bennett, Alex S; Elliott, Luther et al. (2017) Recent Overdose Experiences in a Community Sample of Military Veterans Who Use Opioids. J Drug Issues 47:479-491
Wolfson-Stofko, Brett; Bennett, Alex S; Elliott, Luther et al. (2017) Drug use in business bathrooms: An exploratory study of manager encounters in New York City. Int J Drug Policy 39:69-77
Pouget, Enrique R; Bennett, Alex S; Elliott, Luther et al. (2017) Development of an opioid-related Overdose Risk Behavior Scale (ORBS). Subst Abus 38:239-244
Bennett, Alex S; Elliott, Luther; Golub, Andrew et al. (2017) Opioid-Involved Overdose Among Male Afghanistan/Iraq-Era U.S. Military Veterans: A Multidimensional Perspective. Subst Use Misuse 52:1701-1711
Herzberg, David; Guarino, Honoria; Mateu-Gelabert, Pedro et al. (2016) Recurring Epidemics of Pharmaceutical Drug Abuse in America: Time for an All-Drug Strategy. Am J Public Health 106:408-10
Vazan, Peter; Golub, Andrew; Bennett, Alex S (2015) PTSD, Depression, Daily Stressors, and Treatment Pathways Among Urban Veterans. Mil Behav Health 3:108-115

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