This research is a psychoacoustic investigation into the limitations imposed on auditory analysis by sensorineural hearing loss and the mechanisms of peripheral processing most affected by cochlear pathology. It focuses on the linearized response growth associated with cochlear pathology, which modern physiological research has shown to be a fundamental mechanism of cochlear dysfunction, and which promises to largely explain both abnormal temporal resolution and abnormal frequency resolution in persons with cochlear hearing loss. The research will employ nonsimultaneous masking to obtain valid and reliable psychoacoustic measures of response growth and will quantify the relation between response growth and amount of hearing loss, which will be of significant value for the design of hearing-aid compression schemes in individual patients. The research will also investigate cochlear transduction mechanisms and the types of cochlear damage underlying cochlear hearing loss in individual patients through the use of psychoacoustic measures of low-frequency acoustic biasing, which recent physiological research, of basilar-membrane vibration and auditory-nerve response, has shown to directly reflect basic cochlear transduction processes in outer and innerhair cells. The results of the acoustic biasing experiments may lead to better differential diagnoses of underlying cochlear pathologies in individual patients and thereby point the way to more effective treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
2R01DC000149-18A1
Application #
2456124
Study Section
Hearing Research Study Section (HAR)
Project Start
1979-07-01
Project End
2002-11-30
Budget Start
1997-12-01
Budget End
1998-11-30
Support Year
18
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Wojtczak, M; Schroder, A C; Kong, Y Y et al. (2001) The effect of basilar-membrane nonlinearity on the shapes of masking period patterns in normal and impaired hearing. J Acoust Soc Am 109:1571-86