Although the cochlear implant is among the most successful of neural prostheses, there remains extreme variability in hearing results enjoyed by implant recipients. Thus open set word recognition scores vary between 0% and over 95%. In addition, the immediate and delayed trauma induced by cochlear implantation is extremely variable and in some cases may be progressive and lead to worsening of the word recognition scores achieved postoperatively. The overall objectives of the proposed research in this grant application are (1) to predict and maximize the word recognition scores in patients who have undergone implantation and (2) to limit the immediate and delayed trauma to the inner ear after cochlear implantation. All of the specific Aims are directed toward one or both of these objectives:
Aim 1. Develop, test, and implement patient-specific electro-anatomic models (PSEAMs) and use to identify peripheral anatomic and physiologic factors that limit performance as judged by word recognition scores (overall objective 1).
Aim 2. Perform a correlation study between histologic and radiographic reconstruction of intracochlear electrode position in postmortem human temporal bones (overall objectives 1,2).
Aim 3. Evaluate the preservation of supporting cells of the organ of Corti as possible candidates as progenitor cells in future regenerative therapy following cochlear implantation in the human (overall objective 2).
This Aim will be facilitated greatly by the successful accomplishment of Aim 2, which will allow improved histologic and immunohistochemical studies of these human specimens.
Aim 4. Characterize the cellular immune response to cochlear implantation in the human using lymphoid cell markers for T and B cell subsets (overall objective 2). More than 50% of human specimens from patients who in life have received a cochlear implant demonstrate some evidence of cellular immune response which may cause postoperative degenerative changes including fibrosis, new bone formation and cellular loss which may limit the capacity of regenerative techniques. Better characterization of this cellular immune response may provide opportunity for prevention or medical intervention.
Aim 5. Evaluate the histopathologic changes in temporal bones from humans with otosclerosis and cochlear implantation (overall objectives 1 and 2). Otosclerosis is extremely common in the human population (approximately 1 in 10 individuals) and has been well documented to cause incomplete or aberrant insertion of electrodes in some cases, and may require alteration of the stimulus strategy.
Aim 6 (formerly Aim 7). Continue the accrual of well documented human temporal bones from patients who in life had undergone cochlear implantation (overall objectives 1 and 2).
This grant application proposes research that is based on a unique resource of human temporal bones collected at the Massachusetts Eye and Ear Infirmary including specimens from 59 human subjects who in life had undergone cochlear implantation. The overall purpose and objectives of this research is the development of strategies to (1) predict and maximize word recognition scores for profoundly hearing impaired individuals using the cochlear implant and (2) to limit intraoperative and postoperative trauma to the structures of the inner ear including cells of the organ of Corti that may be critical for successful implantation and also for future forms of therapy such as regeneration of the inner ear.
|Burgess, Barbara J; O'Malley, Jennifer T; Kamakura, Takefumi et al. (2016) Histopathology of the Human Inner Ear in the p.L114P COCH Mutation (DFNA9). Audiol Neurootol 21:88-97|
|Kamakura, Takefumi; Nadol Jr, Joseph B (2016) Correlation between word recognition score and intracochlear new bone and fibrous tissue after cochlear implantation in the human. Hear Res 339:132-41|
|Kamakura, Takefumi; Nadol Jr, Joseph B (2016) Cochlear Histopathology as Observed in Two Patients With a Cochlear Implant Electrode With Positioner. Otol Neurotol 37:642-6|
|Quesnel, Alicia M; Nakajima, Hideko Heidi; Rosowski, John J et al. (2016) Delayed loss of hearing after hearing preservation cochlear implantation: Human temporal bone pathology and implications for etiology. Hear Res 333:225-34|
|Nadol Jr, Joseph B; Handzel, Ophir; Amr, Sami (2015) Histopathology of the Human Inner Ear in a Patient With Sensorineural Hearing Loss Caused by a Variant in DFNA5. Otol Neurotol 36:1616-21|
|Seyyedi, Mohammad; Viana, Lucas M; Nadol Jr, Joseph B (2014) Within-subject comparison of word recognition and spiral ganglion cell count in bilateral cochlear implant recipients. Otol Neurotol 35:1446-50|
|Seyyedi, Mohammad; Viana, Lucas M; Nadol Jr, Joseph B (2014) Within-Subject Comparison of Word Recognition and Spiral Ganglion Cell Count in Bilateral Cochlear Implant Recipients. Otol Neurotol :|
|Seyyedi, Mohammad; Nadol Jr, Joseph B (2014) Intracochlear inflammatory response to cochlear implant electrodes in humans. Otol Neurotol 35:1545-51|
|O'Malley, Jennifer T; Burgess, Barbara J; Zhu, Meng-Yu et al. (2014) Correlation between histologic and radiographic reconstruction of intracochlear electrode position in human temporal bones. Audiol Neurootol 19:184-92|
|Seyyedi, Mohammad; Eddington, Donald K; Nadol Jr, Joseph B (2013) Effect of monopolar and bipolar electric stimulation on survival and size of human spiral ganglion cells as studied by postmortem histopathology. Hear Res 302:9-16|
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