This long-running grant deals with the persistent language impairment that results from left hemisphere stroke (chronic aphasia). Over the years, it produced new aphasia assessment tools, experimental methods, and computational and statistical techniques, and made these available to the research community. Unique to our approach is the emphasis on linking data to implemented computational models of individual patients and patient variability that are derived from psycholinguistic and cognitive principles. These data and models now form the backbone of lesion-mapping and learning studies that are the focus of the next cycle. Building on our success in applying group-level, voxel-based lesion-symptom mapping (VLSM) methodology, the next cycle will introduce new enhancements in the form of multivariate lesion-behavior mapping at the level of voxels, regions, and tracks. Coupling these powerful techniques to our model-driven behavioral analysis ensures that the """"""""symptoms"""""""" that are mapped are realistic with respect to psycholinguistic models, and meaningful with respect to patient performance.
Specific aims are to identify lesion correlates of impairments at conceptual, lexical-semantic, and lexical-phonological stages of word production. There is consensus on the need to bridge the gap between theory and practice in language rehabilitation. Towards this end, a series of studies are proposed that aim to articulate principles of learning in connection with the learning-based recovery of lexical- semantic and lexical-phonological access to words in aphasia. As in our past work, the innovation is the linking of individual patients and patient variability to theory and models. Specifically, we strive to formulate principles of learning that specify how impairment in the lexical access system affects the system's ability to monitor its own state, strengthen weights through repetition, learn from errors, and so on. Such principles constitute building blocks for effective, individually tailored treatment strategies. They are building blocks, too, for learning-based approaches to recovery of other, more complex language functions.

Public Health Relevance

Our research is relevant to the diagnosis of acquired disorders of language, the mapping of language functions in the human brain, and the development of theoretically motivated rehabilitation strategies. An ongoing commitment is to provide ready access by others to the methods and data developed under this project.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000191-32
Application #
8517636
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Cooper, Judith
Project Start
1982-04-01
Project End
2016-08-31
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
32
Fiscal Year
2013
Total Cost
$568,174
Indirect Cost
$133,805
Name
Albert Einstein Medical Center (Philadelphia)
Department
Type
DUNS #
148406911
City
Philadelphia
State
PA
Country
United States
Zip Code
19141
Schwartz, Myrna F; Middleton, Erica L; Brecher, Adelyn et al. (2016) Does naming accuracy improve through self-monitoring of errors? Neuropsychologia 84:272-81
Pustina, Dorian; Coslett, H Branch; Turkeltaub, Peter E et al. (2016) Automated segmentation of chronic stroke lesions using LINDA: Lesion identification with neighborhood data analysis. Hum Brain Mapp 37:1405-21
Kittredge, Audrey K; Dell, Gary S (2016) Learning to speak by listening: Transfer of phonotactics from perception to production. J Mem Lang 89:8-22
Middleton, Erica L; Schwartz, Myrna F; Rawson, Katherine A et al. (2015) Test-enhanced learning versus errorless learning in aphasia rehabilitation: testing competing psychological principles. J Exp Psychol Learn Mem Cogn 41:1253-61
Warker, Jill A; Dell, Gary S (2015) New phonotactic constraints learned implicitly by producing syllable strings generalize to the production of new syllables. J Exp Psychol Learn Mem Cogn 41:1902-10
Mirman, Daniel; Chen, Qi; Zhang, Yongsheng et al. (2015) Neural organization of spoken language revealed by lesion-symptom mapping. Nat Commun 6:6762
Jacobs, Cassandra L; Yiu, Loretta K; Watson, Duane G et al. (2015) Why are repeated words produced with reduced durations? Evidence from inner speech and homophone production. J Mem Lang 84:37-48
Mirman, Daniel; Zhang, Yongsheng; Wang, Ze et al. (2015) The ins and outs of meaning: Behavioral and neuroanatomical dissociation of semantically-driven word retrieval and multimodal semantic recognition in aphasia. Neuropsychologia 76:208-19
Middleton, Erica L; Chen, Qi; Verkuilen, Jay (2015) Friends and foes in the lexicon: homophone naming in aphasia. J Exp Psychol Learn Mem Cogn 41:77-94
Schwartz, Myrna F (2015) The Marin Lab at the Dawn of Cognitive Neuropsychology. Cogn Behav Neurol 28:122-6

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