Obesity occurs because individuals regularly ingest more calories than they expend. This takes place when the reward value of the food is greater than the sum of the satiety signals arising in the gut. Nevertheless, the neural mechanisms that assign hedonic value to taste remain unknown. The neural substrates for the decision to whether ingest or reject a food are complete in the brainstem. In rats, the brainstem contains the first and second central relays for both the gustatory and vagal visceral afferent systems, the motoneurons responsible for ingestive behavior, and sufficient integrative capacity to make this decision. Nevertheless, control of ingestion requires connections to and from the forebrain because disconnecting it from the brainstem eliminates voluntary eating. Writ large, the goal of this research is to understand how the forebrain interacts with these hindbrain mechanisms to bring about the smooth, nuanced control of feeding behavior that characterizes omnivores such as rats and humans. Using behavioral, neuroanatomical, neurochemical, and electrophysiological analysis, this project will test hypotheses about how the reward value of gustatory stimuli is elaborated in the brain.
The first Aim i s to further determine the specific ventral forebrain projections from the parabrachial nuclei that are critical for modulating dopamine release as a function of the rewarding (and aversive) properties of taste stimuli.
Aim 2 addresses functional correlates of those connections by comparing dopamine release in the nucleus accumbens and the central nucleus of the amygdala -- putative nodes in the forebrain reward system -- during homeostatic and hedonic ingestion.
Aim 3 focuses on gustatory neural activity in the pontine taste relays while varying both oral and postoral taste stimulation. The findings will aid in understanding basic regulatory mechanisms that fail to control intake in individuals susceptible to developing dietary obesity due to increased stimulation from augmented palatability of the modern diet.

Public Health Relevance

Palatable foods stimulate intake beyond physiological needs, an effect that leads to obesity. To understand the sensory integration responsible for such hedonic eating, we will examine gustatory neural responses and central dopamine release during oral sucrose stimulation. This project will help us determine how a normally well regulated behavior, such as eating, can go so far awry as to cause an epidemic.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000240-32
Application #
8642614
Study Section
Neurobiology of Motivated Behavior Study Section (NMB)
Program Officer
Sullivan, Susan L
Project Start
1988-03-01
Project End
2015-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
32
Fiscal Year
2014
Total Cost
$319,041
Indirect Cost
$113,341
Name
Pennsylvania State University
Department
Neurosciences
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Simmons, Dwayne D; Lohr, Rachel; Wotring, Helena et al. (2014) Recovery of otoacoustic emissions after high-level noise exposure in the American bullfrog. J Exp Biol 217:1626-36
Dayawansa, Samantha; Ruch, Stacey; Norgren, Ralph (2014) Parabrachial-hypothalamic interactions are required for normal conditioned taste aversions. Am J Physiol Regul Integr Comp Physiol 306:R190-200
Armbruszt, Simon; Abraham, Hajnalka; Figler, Maria et al. (2013) Cocaine- and amphetamine-regulated transcript (CART) peptide immunoreactivity in feeding- and reward-related brain areas of young OLETF rats. J Chem Neuroanat 50-51:75-84
Liang, Nu-Chu; Grigson, Patricia S; Norgren, Ralph (2012) Pontine and thalamic influences on fluid rewards: II. Sucrose and corn oil conditioned aversions. Physiol Behav 105:589-94
Liang, Nu-Chu; Norgren, Ralph; Grigson, Patricia S (2012) Pontine and thalamic influences on fluid rewards: III. Anticipatory contrast for sucrose and corn oil. Physiol Behav 105:595-606
Liang, Nu-Chu; Freet, Christopher S; Grigson, Patricia S et al. (2012) Pontine and thalamic influences on fluid rewards: I. Operant responding for sucrose and corn oil. Physiol Behav 105:576-88
Pritchett, Carolyn E; Hajnal, Andras (2011) Obesogenic diets may differentially alter dopamine control of sucrose and fructose intake in rats. Physiol Behav 104:111-6
Bello, Nicholas T; Hajnal, Andras (2010) Dopamine and binge eating behaviors. Pharmacol Biochem Behav 97:25-33
Horn, Charles C; De Jonghe, Bart C; Matyas, Kathleen et al. (2009) Chemotherapy-induced kaolin intake is increased by lesion of the lateral parabrachial nucleus of the rat. Am J Physiol Regul Integr Comp Physiol 297:R1375-82
Hajnal, Andras; Norgren, Ralph; Kovacs, Peter (2009) Parabrachial coding of sapid sucrose: relevance to reward and obesity. Ann N Y Acad Sci 1170:347-64

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