Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
2R01DC000304-11
Application #
2125406
Study Section
Hearing Research Study Section (HAR)
Project Start
1984-09-01
Project End
2000-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
11
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Pan, Bifeng; Akyuz, Nurunisa; Liu, Xiao-Ping et al. (2018) TMC1 Forms the Pore of Mechanosensory Transduction Channels in Vertebrate Inner Ear Hair Cells. Neuron 99:736-753.e6
Corey, David P; Akyuz, Nurunisa; Holt, Jeffrey R (2018) Function and Dysfunction of TMC Channels in Inner Ear Hair Cells. Cold Spring Harb Perspect Med :
Pan, Bifeng; Askew, Charles; Galvin, Alice et al. (2017) Gene therapy restores auditory and vestibular function in a mouse model of Usher syndrome type 1c. Nat Biotechnol 35:264-272
Christensen, Adam P; Akyuz, Nurunisa; Corey, David P (2016) The Outer Pore and Selectivity Filter of TRPA1. PLoS One 11:e0166167
Delling, M; Indzhykulian, A A; Liu, X et al. (2016) Primary cilia are not calcium-responsive mechanosensors. Nature 531:656-60
Asadnia, Mohsen; Kottapalli, Ajay Giri Prakash; Karavitaki, K Domenica et al. (2016) From Biological Cilia to Artificial Flow Sensors: Biomimetic Soft Polymer Nanosensors with High Sensing Performance. Sci Rep 6:32955
Corey, David P; Holt, Jeffrey R (2016) Are TMCs the Mechanotransduction Channels of Vertebrate Hair Cells? J Neurosci 36:10921-10926
Vogl, Christian; Panou, Iliana; Yamanbaeva, Gulnara et al. (2016) Tryptophan-rich basic protein (WRB) mediates insertion of the tail-anchored protein otoferlin and is required for hair cell exocytosis and hearing. EMBO J 35:2536-2552
Wu, Xudong; Indzhykulian, Artur A; Niksch, Paul D et al. (2016) Hair-Cell Mechanotransduction Persists in TRP Channel Knockout Mice. PLoS One 11:e0155577
Kwan, Kelvin Y; Shen, Jun; Corey, David P (2015) C-MYC transcriptionally amplifies SOX2 target genes to regulate self-renewal in multipotent otic progenitor cells. Stem Cell Reports 4:47-60

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