Hearing-impaired individuals indicate as one of their greatest disabilities the inability to segregate sounds of interest from a complex auditory scene. In normal-hearing listeners, sound segregation is enhanced by localization of the relevant sound source(s), by spatial release from masking, and by spatial stream segregation. The cortical substrates of these three aspects of spatial hearing will be examined using closely coordinated psychophysical studies in humans and cats combined with cortical recording from cats in anesthetized and awake-behaving conditions.
Specific Aim 1 tests the hypothesis that the spatial selectivity of cortical neurons is sharpened when a cat is actively engaged in a localization task compared to when it is inattentive. Further, it will test the hypothesis that such task-dependent sharpening of spatial selectivity is enhanced in particular cortical areas that have been shown to be necessary for normal sound localization behavior.
Specific Aim 2 will define the cortical mechanisms for spatial release from masking. It will characterize spatial release from energetic masking and will develop a novel animal model for informational masking. It will test the hypothesis that informational masking arises at the level of auditory cortex and that spatial masking release is enhanced in auditory cortical belt areas.
Specific Aim 3 develops an animal model for study of spatial stream segregation at the cortical level. It tests the hypothesis that perceptually segregated streams correspond to discrete populations of activated neurons. In addition, it tests the hypothesis that cortical areas that are specialized for spatial stream segregation are distinct from those specialized for sound localization. All three specific aims will discriminate between sub-cortical and cortical mechanisms and will test whether particular aspects of spatial hearing are mediated by distinct cortical areas. This will aid in diagnosis and treatment of spatial hearing disorders.
Aims 2 and 3 will isolate and quantify the contribution of specific low- and high-frequency spatial cues to spatial release from masking and to spatial stream segregation. Understanding of the relative importance of low-frequency fine- structure cues and high-frequency sound-level cues will inform design of sound processing schemes intended to enhance hearing in complex auditory scenes by users of hearing aids and cochlear implants.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
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Study Section
Auditory System Study Section (AUD)
Program Officer
Platt, Christopher
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University of California Irvine
Schools of Medicine
United States
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Javier, Lauren K; McGuire, Elizabeth A; Middlebrooks, John C (2016) Spatial Stream Segregation by Cats. J Assoc Res Otolaryngol 17:195-207
Yao, Justin D; Bremen, Peter; Middlebrooks, John C (2015) Transformation of spatial sensitivity along the ascending auditory pathway. J Neurophysiol 113:3098-111
Yao, Justin D; Bremen, Peter; Middlebrooks, John C (2015) Emergence of Spatial Stream Segregation in the Ascending Auditory Pathway. J Neurosci 35:16199-212
Pham, Carol Q; Bremen, Peter; Shen, Weidong et al. (2015) Central Auditory Processing of Temporal and Spectral-Variance Cues in Cochlear Implant Listeners. PLoS One 10:e0132423
Yao, Justin D; Bremen, Peter; Middlebrooks, John C (2013) Rat primary auditory cortex is tuned exclusively to the contralateral hemifield. J Neurophysiol 110:2140-51
Middlebrooks, John C; Nick, Harry S; Subramony, S H et al. (2013) Mutation in the kv3.3 voltage-gated potassium channel causing spinocerebellar ataxia 13 disrupts sound-localization mechanisms. PLoS One 8:e76749
Middlebrooks, John C (2013) High-acuity spatial stream segregation. Adv Exp Med Biol 787:491-9
Middlebrooks, John C; Bremen, Peter (2013) Spatial stream segregation by auditory cortical neurons. J Neurosci 33:10986-1001
Bremen, Peter; Middlebrooks, John C (2013) Weighting of spatial and spectro-temporal cues for auditory scene analysis by human listeners. PLoS One 8:e59815
Macpherson, Ewan A; Sabin, Andrew T (2013) Vertical-plane sound localization with distorted spectral cues. Hear Res 306:76-92

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