This research program in developmental phonological disorders has the long term objectives of description, explanation, prediction, management, and prevention. The current proposal includes 10 study areas to enhance and test a research model that has guided methodologic and substantive studies since 1980. The model divides relevant independent and dependent variables in developmental phonological disorders into three primary domains, Speech Status, Causal Status, and Management Status. The goal of the current proposal is to conduct three tests of a predictive hypothesis about speech normalization following indirect (caregiver-based) and direct (clinician-based) management. The predictive hypothesis is that of 15 putative subdomains within Speech Status, a speech-delayed child's Metalinguistic Status, which subsumes three constructs -- Metaphonological Status, Motivational Status, and Stimulability--predicts the most significant portion of variance in speech normalization. In Year I, a total of five studies will enhance methods and provide substantive information from a database of children with speech delays of known and unknown origin. In Year II, a total of four studies will yield procedures and information for remaining methodological needs, including prospective data on prediction from two longitudinal data sets. In Year III the predictive hypothesis will be tested in 18 prospective, single-subject intervention designs. Six of the studies will use the unique minicomputer database containing over 1200 comprehensive speech records and diagnostic information (over 4,700 fields per file) from 383 subjects with speech delays of known and unknown origin. Findings from this proposal are expected to impact currently unresolved service delivery questions for the 2.5% of preschool children identified as having speech disorders of heretofore unknown origin. The immediate goal is to isolate and explicate processes underlying normalization with and without intervention. Long term aims are focused on primary, secondary, and tertiary forms of prevention (Asha, 1982; 1987).

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC000496-05
Application #
3217006
Study Section
Sensory Disorders and Language Study Section (CMS)
Project Start
1988-07-01
Project End
1994-06-30
Budget Start
1992-07-01
Budget End
1994-06-30
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Snijders Blok, Lot; Rousseau, Justine; Twist, Joanna et al. (2018) CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language. Nat Commun 9:4619
Shriberg, Lawrence D; Strand, Edythe A; Fourakis, Marios et al. (2017) A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: I. Development and Description of the Pause Marker. J Speech Lang Hear Res 60:S1096-S1117
Shriberg, Lawrence D; Strand, Edythe A; Fourakis, Marios et al. (2017) A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: Introduction. J Speech Lang Hear Res 60:S1094-S1095
Shriberg, Lawrence D; Strand, Edythe A; Fourakis, Marios et al. (2017) A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: IV. The Pause Marker Index. J Speech Lang Hear Res 60:S1153-S1169
Shriberg, Lawrence D; Strand, Edythe A; Fourakis, Marios et al. (2017) A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: III. Theoretical Coherence of the Pause Marker with Speech Processing Deficits in Childhood Apraxia of Speech. J Speech Lang Hear Res 60:S1135-S1152
Shriberg, Lawrence D; Strand, Edythe A; Fourakis, Marios et al. (2017) A Diagnostic Marker to Discriminate Childhood Apraxia of Speech From Speech Delay: II. Validity Studies of the Pause Marker. J Speech Lang Hear Res 60:S1118-S1134
Truong, D T; Shriberg, L D; Smith, S D et al. (2016) Multipoint genome-wide linkage scan for nonword repetition in a multigenerational family further supports chromosome 13q as a locus for verbal trait disorders. Hum Genet 135:1329-1341
Mueller, Kathryn L; Murray, Jeffrey C; Michaelson, Jacob J et al. (2016) Common Genetic Variants in FOXP2 Are Not Associated with Individual Differences in Language Development. PLoS One 11:e0152576
Evans, P D; Mueller, K L; Gamazon, E R et al. (2015) A genome-wide sib-pair scan for quantitative language traits reveals linkage to chromosomes 10 and 13. Genes Brain Behav 14:387-97
Strand, Edythe A; Duffy, Joseph R; Clark, Heather M et al. (2014) The Apraxia of Speech Rating Scale: a tool for diagnosis and description of apraxia of speech. J Commun Disord 51:43-50

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