We will investigate the cognitive organization of word processing, verbal short-term memory (STM) and word learning. These three capacities are fundamental to learning, and their integrity has implications for rehabilitation of neurologically-based language deficits. We propose to continue our studies of the effects of semantic and phonological impairment on language, STM and learning abilities of individuals with aphasia and will extend these analyses to individuals with semantic dementia. Our focus will be on the detrimental effects of semantic impairments on learning and response to treatment in these populations. Semantic impairments are present in both semantic dementia and aphasia but are manifested differently in the two populations. These differences are as yet not fully understood but are broadly characterized as semantic access vs. semantic knowledge impairments. Our goal is to elucidate the behavioral and neuroanatomical features of semantic access and knowledge disorders and the effects of each on word processing, STM and learning. We will obtain behavioral and neuroimaging data (structural MRI scans) on four groups defined by the etiology of their impairment (aphasia, semantic dementia) and locus of disruption within a psycholinguistic model of word processing. Additionally, we will identify factors that stress semantic short- term working memory to test the hypothesis that this factor is at the root of semantic access deficits and that semantic STM deficits are associated with impaired executive functions. In a second project, we will investigate effects of semantic and phonological impairment in aphasia on learning to recognize and produce new words in order to determine how these impairments affect this process. This project is linked to a third ongoing project that investigates priming treatments for word retrieval disorders in aphasia. Here we aim to test the efficacy of a new version of our contextual priming treatment that targets output pathways of naming directly. The cognitive data gathered in these three projects will be brought to bear on the ongioing development of a computational model of verbal STM, word processing and learning.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC001924-15
Application #
7740802
Study Section
Special Emphasis Panel (ZRG1-BBBP-H (03))
Program Officer
Cooper, Judith
Project Start
2005-12-05
Project End
2011-11-30
Budget Start
2009-12-01
Budget End
2011-11-30
Support Year
15
Fiscal Year
2010
Total Cost
$576,083
Indirect Cost
Name
Temple University
Department
Other Health Professions
Type
Schools of Allied Health Profes
DUNS #
057123192
City
Philadelphia
State
PA
Country
United States
Zip Code
19122
Minkina, Irene; Rosenberg, Samantha; Kalinyak-Fliszar, Michelene et al. (2017) Short-Term Memory and Aphasia: From Theory to Treatment. Semin Speech Lang 38:17-28
Peñaloza, Claudia; Mirman, Daniel; Tuomiranta, Leena et al. (2016) Novel word acquisition in aphasia: Facing the word-referent ambiguity of natural language learning contexts. Cortex 79:14-31
Peñaloza, Claudia; Benetello, Annalisa; Tuomiranta, Leena et al. (2015) Speech segmentation in aphasia. Aphasiology 29:724-743
Tuomiranta, Leena; Grönroos, Ann-Mari; Martin, Nadine et al. (2014) Vocabulary acquisition in aphasia: Modality can matter. J Neurolinguistics 32:42-58
Hula, William D; Fergadiotis, Gerasimos; Martin, Nadine (2012) Model choice and sample size in item response theory analysis of aphasia tests. Am J Speech Lang Pathol 21:S38-50
Martin, Nadine; Kohen, Francine; Kalinyak-Fliszar, Michelene et al. (2012) Effects of working memory load on processing of sounds and meanings of words in aphasia. Aphasiology 26:462-493
Laine, Matti; Martin, Nadine (2012) Cognitive Neuropsychology Has Been, Is, And Will Be Significant To Aphasiology. Aphasiology 26:1362-1376
Kalinyak-Fliszar, Michelene; Kohen, Francine; Martin, Nadine (2011) Remediation of language processing in aphasia: Improving activation and maintenance of linguistic representations in (verbal) short-term memory. Aphasiology 25:1095-1131
Kohen, Francine; Milsark, Gary; Martin, Nadine (2011) Effects of syntactic and semantic argument structure on sentence repetition in agrammatism: Things we can learn from particles and prepositions. Aphasiology 25:736-747
Gupta, Prahlad (2008) The role of computational models in investigating typical and pathological behaviors. Semin Speech Lang 29:211-25;quiz C 5-6

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