Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
1R01DC002830-01
Application #
2128342
Study Section
Hearing Research Study Section (HAR)
Project Start
1996-02-01
Project End
2000-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Ohio State University
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210
Novotny, Laura A; Bakaletz, Lauren O (2003) The fourth surface-exposed region of the outer membrane protein P5-homologous adhesin of nontypable Haemophilus influenzae is an immunodominant but nonprotective decoying epitope. J Immunol 171:1978-83
Kyd, Jennelle M; Cripps, Allan W; Novotny, Laura A et al. (2003) Efficacy of the 26-kilodalton outer membrane protein and two P5 fimbrin-derived immunogens to induce clearance of nontypeable Haemophilus influenzae from the rat middle ear and lungs as well as from the chinchilla middle ear and nasopharynx. Infect Immun 71:4691-9
Novotny, Laura A; Pichichero, Michael E; Denoel, Philippe A et al. (2002) Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media. Vaccine 20:3590-7
Bakaletz, L O (2001) Peptide and recombinant antigens for protection against bacterial middle ear infection. Vaccine 19:2323-8
Kennedy, B J; Novotny, L A; Jurcisek, J A et al. (2000) Passive transfer of antiserum specific for immunogens derived from a nontypeable Haemophilus influenzae adhesin and lipoprotein D prevents otitis media after heterologous challenge. Infect Immun 68:2756-65
Novotny, L A; Jurcisek, J A; Pichichero, M E et al. (2000) Epitope mapping of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae. Infect Immun 68:2119-28
Holmes, K A; Bakaletz, L O (1997) Adherence of non-typeable Haemophilus influenzae promotes reorganization of the actin cytoskeleton in human or chinchilla epithelial cells in vitro. Microb Pathog 23:157-66
Bakaletz, L O; Leake, E R; Billy, J M et al. (1997) Relative immunogenicity and efficacy of two synthetic chimeric peptides of fimbrin as vaccinogens against nasopharyngeal colonization by nontypeable Haemophilus influenzae in the chinchilla. Vaccine 15:955-61