Abstract

The long-term goal of the applicant's research is to understand how humans adapt to vestibular disorders with the practical aim of developing better physical therapy programs for patients with vestibular disorders. The specific objective of this proposal is to learn more about the mechanisms underlying short-term (minutes to hours) VOR adaptation in normal humans. The emphasis is upon adaptive control of 1) otolith-ocular reflexes, 2) the phase of the canal and otolith-ocular reflexes, and 3) the torsional VOR. The applicants will evaluate the error signals, contextual cues, and any preprogrammed responses that lead to the expression of adapted VORs. Relatively little is known about these aspects of vestibular physiology and each potentially bears on important issues related to vestibular adaptation, the error signals that drive it, and how adaptive compensation might be promoted in patients.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC002849-04
Application #
6043371
Study Section
Hearing Research Study Section (HAR)
Project Start
1996-08-01
Project End
2001-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Walker, M F; Shelhamer, M; Zee, D S (2004) Eye-position dependence of torsional velocity during interaural translation, horizontal pursuit, and yaw-axis rotation in humans. Vision Res 44:613-20
Shelhamer, Mark; Zee, David S (2003) Context-specific adaptation and its significance for neurovestibular problems of space flight. J Vestib Res 13:345-62
Trillenberg, P; Shelhamer, M; Roberts, D C et al. (2003) Cross-axis adaptation of torsional components in the yaw-axis vestibulo-ocular reflex. Exp Brain Res 148:158-65
Eggers, Sscott D Z; De Pennington, Nick; Walker, Mark F et al. (2003) Short-term adaptation of the VOR: non-retinal-slip error signals and saccade substitution. Ann N Y Acad Sci 1004:94-110
Shelhamer, Mark; Clendaniel, Richard A (2002) Context-specific adaptation of saccade gain. Exp Brain Res 146:441-50
Shelhamer, Mark; Peng, Grace C Y; Ramat, Stefano et al. (2002) Context-specific adaptation of the gain of the oculomotor response to lateral translation using roll and pitch head tilts as contexts. Exp Brain Res 146:388-93
Shelhamer, Mark; Clendaniel, Richard (2002) Sensory, motor, and combined contexts for context-specific adaptation of saccade gain in humans. Neurosci Lett 332:200-4
Trillenberg, P; Zee, D S; Shelhamer, M (2002) On the distribution of fast-phase intervals in optokinetic and vestibular nystagmus. Biol Cybern 87:68-78
Ramat, S; Zee, D S (2002) Translational VOR responses to abrupt interaural accelerations in normal humans. Ann N Y Acad Sci 956:551-4
Shelhamer, M (2001) Use of a genetic algorithm for the analysis of eye movements from the linear vestibulo-ocular reflex. Ann Biomed Eng 29:510-22

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