The ultimate aim of this research is to improve our understanding of physical mechanisms of normal and disordered voice production. Using a variety of laboratory models of vocal fold vibration (physical models, excised human larynx modes, in vivo canine laryngeal models), the proposed research will investigate mechanisms of regular and irregular vibration by quantifying the medial surface dynamics of the vocal folds. Access to the medial surface will be obtained through means a hemi-larynx methodology, and high-speed, stereoscopic, digital imaging. Medial surface dynamics captures the propagation of the mucosal wave, the existence of which is generally understood to be a necessary condition of phonation. With access to medial surface dynamics, spatio-temporal analyses will reduce the data to essential dynamics to help disclose physical mechanisms of vibration. With this focus on medial surface dynamics, the following Specific Aims will be pursued: (1) Identify and characterize the phonation types which occur as a function of glottal adduction, (2) Identify and characterize the phonation types which occur as a function of viscoelastic and geometric changes in the body/cover structure of the vocal folds, (3) Identify and characterize the phonation types which occur as a function or source-resonator coupling, (4) Identify and characterize the phonation types which occur as a function of left-right asymmetries, (5) Clarify the degree to which an endoscopic view of the vocal folds can or cannot disclose physical mechanisms of normal and disordered voice production. Contrast the information regarding physical mechanisms of vibration that can be extracted from acoustic spectrograms, spatio-temporal analyses of the superior surface of the vocal folds, and spatio-temporal analyses of the medial surface of the vocal folds.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC003072-15
Application #
7826615
Study Section
Special Emphasis Panel (ZRG1-BBBP-E (02))
Program Officer
Shekim, Lana O
Project Start
1997-05-01
Project End
2012-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
15
Fiscal Year
2010
Total Cost
$358,920
Indirect Cost
Name
University of California Los Angeles
Department
Surgery
Type
Schools of Medicine
DUNS #
092530369
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Yang, Anxiong; Berry, David A; Kaltenbacher, Manfred et al. (2012) Three-dimensional biomechanical properties of human vocal folds: parameter optimization of a numerical model to match in vitro dynamics. J Acoust Soc Am 131:1378-90
Dollinger, Michael; Berry, David A; Luegmair, Georg et al. (2012) Effects of the epilarynx area on vocal fold dynamics and the primary voice signal. J Voice 26:285-92
Chhetri, Dinesh K; Neubauer, Juergen; Berry, David A (2012) Neuromuscular control of fundamental frequency and glottal posture at phonation onset. J Acoust Soc Am 131:1401-12
Yang, Anxiong; Stingl, Michael; Berry, David A et al. (2011) Computation of physiological human vocal fold parameters by mathematical optimization of a biomechanical model. J Acoust Soc Am 130:948-64
Chhetri, Dinesh K; Zhang, Zhaoyan; Neubauer, Juergen (2011) Measurement of Young's modulus of vocal folds by indentation. J Voice 25:1-7
Schmidt, Bastian; Stingl, Michael; Leugering, Gunter et al. (2011) Material parameter computation for multi-layered vocal fold models. J Acoust Soc Am 129:2168-80
Dollinger, M; Berry, D A; Huttner, B et al. (2011) Assessment of local vocal fold deformation characteristics in an in vitro static tensile test. J Acoust Soc Am 130:977-85
Chhetri, Dinesh K; Neubauer, Juergen; Berry, David A (2010) Graded activation of the intrinsic laryngeal muscles for vocal fold posturing. J Acoust Soc Am 127:EL127-33
Yang, Anxiong; Lohscheller, Jorg; Berry, David A et al. (2010) Biomechanical modeling of the three-dimensional aspects of human vocal fold dynamics. J Acoust Soc Am 127:1014-31
Zhang, Zhaoyan (2010) Dependence of phonation threshold pressure and frequency on vocal fold geometry and biomechanics. J Acoust Soc Am 127:2554-62

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