Exploring Auditory Mechanics with Pressure and Motion Measurements. The series of experiments proposed here use pressure sensors and other special techniques developed in our lab, complemented by well-established methods like laser-doppler velocimetry, to explore auditory mechanics. The projects of the first four aims continue and extend our previous work on inner and middle ear mechanics.
The final aim develops and evaluates a new method for deep cochlear implant insertion. Sound input causes a wave-pattern of sensory tissue motion within the inner ear that is conveyed to the auditory nerve, leading to hearing. This takes place within cochlear compartments having very limited experimental accessibility.
Aims one and two of the studies proposed here will push into these barely accessible compartments with specialized micro-sensors.
Aim one uses a further miniaturized micro-pressure sensor for in vivo measurements of scala media pressure.
Aim two advances our lab's well- established scala tympani pressure measurements by combining them with cochlear microphonic measurements at the same location, within micrometers of the organ of Corti.
Both aims are designed to test specific theoretical predictions in order to have a strong impact on the advancement of knowledge. Sound is transmitted by the middle ear with high fidelity even at frequencies where the eardrum has a complex, random-wavy response to sound. Recent theories employ the eardrum wave for sound transmission, and our aim three tests that prediction by changing the wave speed with stiffening agents, measuring the wave speed with a laser velocimeter and also monitoring sound transmission with intracochlear pressure. Our second middle ear aim explores a theoretical prediction that the air cavity behind the eardrum provides reflection that is the basis for good sound transmission at high frequencies. Finally, our last aim explores a novel method for deep cochlear implant insertion using viscous forces. The method will by evaluated physiologically in the proposed studies.

Public Health Relevance

Exploring auditory mechanics with pressure and motion measurements. The core objective of the project is to understand the mechanical processing of the auditory periphery: how the middle ear effectively transmits sound to the inner ear, and the mechanical processing that leads to a frequency-sorted pattern of vibration along the long narrow strip of sensory tissue in the inner ear. Additionally, we have developed a non-traumatic method of cochlear implant insertion and will further develop and test this method. We use micro-pressure-sensors that were developed in our laboratory, and laser-based methods for measuring tiny motions, in order to test current theories of the operation of the ear and measure mechanical responses in implanted inner ears.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC003130-18
Application #
8227963
Study Section
Auditory System Study Section (AUD)
Program Officer
Cyr, Janet
Project Start
1996-03-01
Project End
2016-02-29
Budget Start
2012-03-01
Budget End
2013-02-28
Support Year
18
Fiscal Year
2012
Total Cost
$342,125
Indirect Cost
$129,625
Name
Columbia University (N.Y.)
Department
Otolaryngology
Type
Schools of Medicine
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032
Bergevin, Christopher; Olson, Elizabeth S (2014) External and middle ear sound pressure distribution and acoustic coupling to the tympanic membrane. J Acoust Soc Am 135:1294-312
Decraemer, W F; de La Rochefoucauld, O; Funnell, W R J et al. (2014) Three-dimensional vibration of the malleus and incus in the living gerbil. J Assoc Res Otolaryngol 15:483-510
Kale, Sushrut; Cervantes, Vanessa M; Wu, Mailing R et al. (2014) A novel perfusion-based method for cochlear implant electrode insertion. Hear Res 314:33-41
Dong, Wei; Olson, Elizabeth S (2013) Detection of cochlear amplification and its activation. Biophys J 105:1067-78
Huang, Stanley; Olson, Elizabeth S (2011) Auditory nerve excitation via a non-traveling wave mode of basilar membrane motion. J Assoc Res Otolaryngol 12:559-75
Eze, N; Olson, E S (2011) Basilar membrane velocity in a cochlea with a modified organ of Corti. Biophys J 100:858-67
Shera, Christopher A; Olson, Elizabeth S; Guinan Jr, John J (2011) On cochlear impedances and the miscomputation of power gain. J Assoc Res Otolaryngol 12:671-6
Nakajima, Hideko Heidi; Dong, Wei; Olson, Elizabeth S et al. (2010) Evaluation of round window stimulation using the floating mass transducer by intracochlear sound pressure measurements in human temporal bones. Otol Neurotol 31:506-11
de La Rochefoucauld, Ombeline; Kachroo, Puja; Olson, Elizabeth S (2010) Ossicular motion related to middle ear transmission delay in gerbil. Hear Res 270:158-72
Nakajima, Hideko Heidi; Dong, Wei; Olson, Elizabeth S et al. (2009) Differential intracochlear sound pressure measurements in normal human temporal bones. J Assoc Res Otolaryngol 10:23-36

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