(From applicant's proposal): Sounds from the ear-known as otoacoustic emissions (OAEs)-are now widely used as clinical diagnostic and screening tools. Nevertheless, relatively little is known about the physical mechanisms that generate and shape them. Thus, although otoacoustic emissions offer a promising noninvasive window on the biophysics of cochlear function, the clinical use of OAEs is currently limited to a largely qualitative assay of hearing threshold. Realizing the considerable potential of OAEs as nonivasive probes of cochlear state requires understanding the role of cochlear nonlinearity, amplification, and middle-ear transmission in shaping the ear-canal spectrum of these sounds. This project focuses on specific issues that probe the mechanisms underlying the generation and propagation of otoacoustic emissions. By combining ear-canal measurements of OAEs in cat with simultaneous measurements of the responses of auditory-nerve fibers and middle-ear transmission, the project explores a number of issues central to any quantitative interpretation of OAE measurements. The measurements will be used to develop and test a comprehensive model of cochlear emissions that will allow ear-canal measurements to be interpreted directly in terms of cochlear mechanics. The model will be combined with measurements of distortion-product emissions to estimate the spatial dependence and gain of the """"""""cochlear amplifier"""""""" and other important characteristics of cochlear physiology. The project lays the necessary groundwork both for improving the clinical utility of current OAE measurements and for developing new, more functionally interpretable measures of cochlear state.
| Shera, Christopher A; Charaziak, Karolina K (2018) Cochlear Frequency Tuning and Otoacoustic Emissions. Cold Spring Harb Perspect Med : |
| Sumner, Christian J; Wells, Toby T; Bergevin, Christopher et al. (2018) Mammalian behavior and physiology converge to confirm sharper cochlear tuning in humans. Proc Natl Acad Sci U S A 115:11322-11326 |
| Gruters, Kurtis G; Murphy, David L K; Jenson, Cole D et al. (2018) The eardrums move when the eyes move: A multisensory effect on the mechanics of hearing. Proc Natl Acad Sci U S A 115:E1309-E1318 |
| Abdala, Carolina; Guardia, Yeini C; Shera, Christopher A (2018) Swept-tone stimulus-frequency otoacoustic emissions: Normative data and methodological considerations. J Acoust Soc Am 143:181 |
| Moleti, Arturo; Sisto, Renata; Shera, Christopher A (2018) Introducing Causality Violation for Improved DPOAE Component Unmixing. AIP Conf Proc 1965: |
| Charaziak, Karolina K; Siegel, Jonathan H; Shera, Christopher A (2018) Spectral Ripples in Round-Window Cochlear Microphonics: Evidence for Multiple Generation Mechanisms. J Assoc Res Otolaryngol 19:401-419 |
| Abdala, Carolina; Ortmann, Amanda J; Shera, Christopher A (2018) Reflection- and Distortion-Source Otoacoustic Emissions: Evidence for Increased Irregularity in the Human Cochlea During Aging. J Assoc Res Otolaryngol 19:493-510 |
| Christensen, Anders T; Abdala, Carolina; Shera, Christopher A (2018) Probing Apical-Basal Differences in the Human Cochlea Using Distortion-Product Otoacoustic Emission Phase. AIP Conf Proc 1965: |
| Sisto, Renata; Shera, Christopher A; Moleti, Arturo (2018) Negative-delay sources in distortion product otoacoustic emissions. Hear Res 360:25-30 |
| Charaziak, Karolina K; Dong, Wei; Shera, Christopher A (2018) Temporal Suppression of Clicked-Evoked Otoacoustic Emissions and Basilar-Membrane Motion in Gerbils. AIP Conf Proc 1965: |
Showing the most recent 10 out of 71 publications
