The long-term goals of this project are to further our understanding of how peripheral auditory processing affects perception, and to investigate the extent to which the physiological changes associated with cochlear damage can account for the perceptual difficulties faced by people with hearing loss.
The first aim i s to investigate behavioral measures of cochlear function in humans. Behavioral methods of estimating basilar-membrane (BM) compression will be compared in terms of accuracy and efficiency in normal-hearing and hearing-impaired listeners. These methods will then be used to assess the effects of broadband noise on estimated BM compression, to test the hypothesis that broadband noise linearizes the response to tones through the effects of suppression. Current behavioral measures of BM compression are not efficient enough for clinical applications. New behavioral measures, suitable for potential clinical use, will therefore be developed. Work will also continue towards providing a comprehensive description of normal and impaired human cochlear filtering over a wide range of frequencies and levels.
The second aim i s to investigate temporal resolution in humans using behavioral measures that, unlike many current measures, are not confounded by the influence of BM compression. This will allow us to test for effects of ageing on temporal processing, independent of the effects of cochlear nonlinearity. It will also allow us to test the hypothesis that listeners who exhibit abnormally poor word recognition for a given hearing loss suffer from deficits in temporal processing.
The third aim i s to use the new measures of BM compression and temporal resolution to predict normal-hearing and hearing-impaired listeners' speech reception thresholds in complex backgrounds, such as fluctuating noise and single-talker interference. This will test the hypothesis that deficits in speech reception by hearing-impaired listeners in complex acoustic environments is influenced both by deficits in cochlear processing and, in some cases, by deficits in higher-level temporal processing. A better understanding of normal cochlear function in humans has many applications, including biologically based front-end processors for speech recognition and improved preprocessors for cochlear implants. Better understanding of the deficits suffered by hearing-impaired listeners should lead to more accurate diagnoses on an individual basis, which in turn should lead to improved hearing aid algorithms and fitting procedures.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC003909-12
Application #
7339864
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Donahue, Amy
Project Start
1999-02-01
Project End
2011-01-31
Budget Start
2008-02-01
Budget End
2011-01-31
Support Year
12
Fiscal Year
2008
Total Cost
$277,924
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychology
Type
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Gregan, Melanie J; Nelson, Peggy B; Oxenham, Andrew J (2013) Behavioral measures of cochlear compression and temporal resolution as predictors of speech masking release in hearing-impaired listeners. J Acoust Soc Am 134:2895-912
Gregan, Melanie J; Nelson, Peggy B; J Oxenham, Andrew (2011) Behavioral estimates of basilar-membrane compression: additivity of forward masking in noise-masked normal-hearing listeners. J Acoust Soc Am 130:2835-44
Wojtczak, Magdalena; Oxenham, Andrew J (2010) Recovery from on- and off-frequency forward masking in listeners with normal and impaired hearing. J Acoust Soc Am 128:247-56
Shera, Christopher A; Guinan Jr, John J; Oxenham, Andrew J (2010) Otoacoustic estimation of cochlear tuning: validation in the chinchilla. J Assoc Res Otolaryngol 11:343-65
Dau, Torsten; Ewert, Stephan; Oxenham, Andrew J (2009) Auditory stream formation affects comodulation masking release retroactively. J Acoust Soc Am 125:2182-8
Wojtczak, Magdalena; Oxenham, Andrew J (2009) On- and off-frequency forward masking by Schroeder-phase complexes. J Assoc Res Otolaryngol 10:595-607
Wojtczak, Magdalena; Oxenham, Andrew J (2009) Pitfalls in behavioral estimates of basilar-membrane compression in humans. J Acoust Soc Am 125:270-81
Gutschalk, Alexander; Micheyl, Christophe; Oxenham, Andrew J (2008) The pulse-train auditory aftereffect and the perception of rapid amplitude modulations. J Acoust Soc Am 123:935-45
Dreyer, Anna A; Oxenham, Andrew J (2008) Effects of level and background noise on interaural time difference discrimination for transposed stimuli. J Acoust Soc Am 123:EL1-7
Plack, Christopher J; Oxenham, Andrew J; Simonson, Andrea M et al. (2008) Estimates of compression at low and high frequencies using masking additivity in normal and impaired ears. J Acoust Soc Am 123:4321-30

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