This proposal hypothesizes that reinfection with CMV occurs frequently in some populations, with symptomatic congenital CMV infection occurring in offspring of immune mothers more frequently than previously recognized. Therefore, a case-control study of intrauterine CMV transmission among young women (less than 20 years of age) who were CMV seropositive prior to pregnancy is proposed with the following specific aims: (1) to determine the rates of reinfection with CMV among young, low-income CMV seropositive women, (2) to determine whether exposure to young children and sexual behavior are associated with reinfection among seropositive women, and (3) to assess whether maternal reinfection increases risk for intrauterine CMV transmission among women with preexisting immunity and (4) to characterize the antiviral antibody responses in those women who did and did not transmit CMV to their infants.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
1R01DC004163-01
Application #
2883885
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Spong, Catherine
Project Start
1999-09-01
Project End
2004-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
1
Fiscal Year
1999
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Pediatrics
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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Yamamoto, Aparecida Yulie; Mussi-Pinhata, Marisa Marcia; Boppana, Suresh B et al. (2010) Human cytomegalovirus reinfection is associated with intrauterine transmission in a highly cytomegalovirus-immune maternal population. Am J Obstet Gynecol 202:297.e1-8
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Dar, Lalit; Pati, Sunil Kumar; Patro, A Raj Kumar et al. (2008) Congenital cytomegalovirus infection in a highly seropositive semi-urban population in India. Pediatr Infect Dis J 27:841-3
Fowler, Karen B; Boppana, Suresh B (2006) Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol 35:226-31
Boppana, Suresh B; Fowler, Karen B; Pass, Robert F et al. (2005) Congenital cytomegalovirus infection: association between virus burden in infancy and hearing loss. J Pediatr 146:817-23

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