Human Auditory Cortex Physiology Speech sounds are the most important sounds that we hear;yet little is known about how these stimuli are represented within human auditory cortex. The goal of our research is to understand the functional organization and connections of those areas of human cerebral cortex that are engaged in sound processing and examine how auditory and visual speech stimuli are represented in these regions. These experiments involve direct electrophysiological recording from, and electrical stimulation of, the cerebral cortex of awake human subjects undergoing clinical evaluation of intractable epilepsy. We will pursue our goals by testing a series of specific hypotheses regarding: 1) the locations and functional properties of auditory cortical fields, 2) the manner in which evoked responses to speech stimuli are represented and transformed within these fields, 3) the influence of visual speech information and competing background noise on cortical processing within these fields, and 4) the functional connections and patterns of information flow between these fields. These objectives are pursued by an experienced multidisciplinary team using direct investigative methods in order to gather complimentary sets of human physiological and anatomical data. The resulting measurements cannot be obtained using non-invasive techniques. We pursue these objectives believing that knowledge of the fundamental structure and function of the normal human auditory system is essential to understanding mechanism that underlie impairment of all aspects of hearing, speech, and language.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC004290-10
Application #
7741240
Study Section
Auditory System Study Section (AUD)
Program Officer
Sklare, Dan
Project Start
2004-08-01
Project End
2010-11-30
Budget Start
2009-12-01
Budget End
2010-11-30
Support Year
10
Fiscal Year
2010
Total Cost
$556,967
Indirect Cost
Name
University of Iowa
Department
Surgery
Type
Schools of Medicine
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242
Nourski, Kirill V (2017) Auditory processing in the human cortex: An intracranial electrophysiology perspective. Laryngoscope Investig Otolaryngol 2:147-156
Nourski, Kirill V; Banks, Matthew I; Steinschneider, Mitchell et al. (2017) Electrocorticographic delineation of human auditory cortical fields based on effects of propofol anesthesia. Neuroimage 152:78-93
Baroni, Fabiano; van Kempen, Jochem; Kawasaki, Hiroto et al. (2017) Intracranial markers of conscious face perception in humans. Neuroimage 162:322-343
Oya, Hiroyuki; Howard, Matthew A; Magnotta, Vincent A et al. (2017) Mapping effective connectivity in the human brain with concurrent intracranial electrical stimulation and BOLD-fMRI. J Neurosci Methods 277:101-112
Katlowitz, Kalman A; Oya, Hiroyuki; Howard 3rd, Matthew A et al. (2017) Paradoxical vocal changes in a trained singer by focally cooling the right superior temporal gyrus. Cortex 89:111-119
Ai, Leo; Xiong, Jinhu (2016) Temporal-spatial mean-shift clustering analysis to improve functional MRI activation detection. Magn Reson Imaging 34:1283-1291
Abel, Taylor J; Rhone, Ariane E; Nourski, Kirill V et al. (2016) Beta modulation reflects name retrieval in the human anterior temporal lobe: an intracranial recording study. J Neurophysiol 115:3052-61
Rhone, Ariane E; Nourski, Kirill V; Oya, Hiroyuki et al. (2016) Can you hear me yet? An intracranial investigation of speech and non-speech audiovisual interactions in human cortex. Lang Cogn Neurosci 31:284-302
Nourski, Kirill V; Steinschneider, Mitchell; Rhone, Ariane E (2016) Electrocorticographic Activation within Human Auditory Cortex during Dialog-Based Language and Cognitive Testing. Front Hum Neurosci 10:202
Behroozmand, Roozbeh; Oya, Hiroyuki; Nourski, Kirill V et al. (2016) Neural Correlates of Vocal Production and Motor Control in Human Heschl's Gyrus. J Neurosci 36:2302-15

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