There is no more vital sensory function than guiding and motivating the selection and consumption of safe and nutritious foods. Much of this function is carried-out by the sensory systems of the mouth and nose which together give rise to the flavor of foods. Although research has focused almost exclusively on the senses of taste and retronasal olfaction, also important are the thermal, mechanical, and chemesthetic components of flavor. The long-term goal of this project is therefore to understand in what ways and via which mechanisms somatosensory stimuli contribute to flavor perception. As in past funding periods, psychophysical studies in the current period have led to the discovery of previously unrecognized effects of temperature and touch on taste and chemesthesis. The proposed project will focus on differential effects of temperature on sweet taste, bitter taste, and oral chemesthesis that have implications for the molecular and cellular mechanisms of gustatory and chemesthetic transduction. Specifically, Aim 1 will test the hypothesis that temperature affects sweet taste primarily by modulating the rate and degree of adaptation, possibly by changes in conformation of the T1R2- T1R3 sweet taste receptor.
Aim 2 will investigate the potential role of the cation channel TPRM5 in the perceptual phenomenon of Thermal Taste and its possible contribution to the counteraction of sweet taste adaptation.
Aim 3 will investigate the differentia effects of temperature on bitter taste perception with the goal of determining the relationship of these effects to different modes of bitter taste transduction, including the possible contribution f TRPM5. Finally, Aim 4 will measure how temperature influences the taste and chemesthetic sensations of salts and acids with the specific goal of testing the hypothesis that their chemesthetic qualities are evoked primarily via different thermally-sensitive TRP channels (i.e. TRPV1 vs. TRPA1). Together these aims will lead to a more complete understanding of the ways in which temperature affects taste and flavor, while also providing unique tests of hypotheses about chemosensory mechanisms in humans that have been developed primarily in animal models. Translational research of this kind is therefore important for advancing our understanding of cellular and molecular mechanisms in humans that could lead to new strategies for addressing dysfunctions of taste and flavor that adversely affect diet and health.

Public Health Relevance

Basic research on human flavor perception is necessary for understanding how the sensory properties of foods help guide food selection and consumption. The goal of the present project is to provide important missing information about how temperature modulates the taste and flavor of foods, and how these effects are related to the cellular and molecular mechanisms of taste and chemesthesis. This fundamental information is important for developing both behavioral and mechanistic strategies to optimize the palatability and thus the consumption of nutritious, low-calorie foods in healthy individuals, and to increase the motivation to eat healthy diets in individuals for whom taste or smell has been impaired by aging or disease.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
2R01DC005002-11A1
Application #
8504277
Study Section
Somatosensory and Chemosensory Systems Study Section (SCS)
Program Officer
Sullivan, Susan L
Project Start
2001-07-01
Project End
2018-01-31
Budget Start
2013-02-15
Budget End
2014-01-31
Support Year
11
Fiscal Year
2013
Total Cost
$364,684
Indirect Cost
$152,184
Name
John B. Pierce Laboratory, Inc.
Department
Type
DUNS #
010139210
City
New Haven
State
CT
Country
United States
Zip Code
06519
Green, Barry G (2013) In pursuit of taste phenotypes. Chem Senses 38:289-92
Green, Barry G; Nachtigal, Danielle; Hammond, Samuel et al. (2012) Enhancement of retronasal odors by taste. Chem Senses 37:77-86
Green, Barry G (2012) Chemesthesis and the chemical senses as components of a "chemofensor complex". Chem Senses 37:201-6
Rudenga, K; Green, B; Nachtigal, D et al. (2010) Evidence for an integrated oral sensory module in the human anterior ventral insula. Chem Senses 35:693-703
Green, Barry G; Lim, Juyun; Osterhoff, Floor et al. (2010) Taste mixture interactions: suppression, additivity, and the predominance of sweetness. Physiol Behav 101:731-7
Lim, Juyun; Urban, Lenka; Green, Barry G (2008) Measures of individual differences in taste and creaminess perception. Chem Senses 33:493-501
Lim, Juyun; Green, Barry G (2008) Tactile interaction with taste localization: influence of gustatory quality and intensity. Chem Senses 33:137-43
Green, Barry G; Akirav, Carol (2007) Individual differences in temperature perception: evidence of common processing of sensation intensity of warmth and cold. Somatosens Mot Res 24:71-84
Lim, Juyun; Green, Barry G (2007) The psychophysical relationship between bitter taste and burning sensation: evidence of qualitative similarity. Chem Senses 32:31-9
Green, Barry G (2005) Lingual heat and cold sensitivity following exposure to capsaicin or menthol. Chem Senses 30 Suppl 1:i201-2

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