A significant barrier to effective research, diagnosis, and treatment of stuttering has been a long history of viewing it as a simple unitary disorder in spite of its immense diversity in presentation and responsiveness to treatment. The broad objective of the first 5-year cycle (plus no cost extension) of this project was to study stuttering onset and development by positing that subtypes account for the diversity. Our theoretical orientation rests on a model that stuttering involves complex, multilevel and dynamic factors that interact to ultimately disrupt speech production. We view stuttering as a complex developmental disorder encompassing subtypes that are both genetically and environmentally shaped, and expressed through differences in the language, motor, and temperament domains, allowing us to parcel out variability that is predictive of recovery, chronicity, and therapeutic efficacy. Specifically, our project has been testing the hypothesis of distinct subtypes in developmental stuttering with data from over 200 longitudinal and cross-sectional participants in three age groups, combined with data from control subjects as well as from children's parents (a total of 851 participants). The project has a three-part agenda: Part 1: The core longitudinal study of early stuttering maps the longitudinal pathways of stuttering development in preschool children across the domains of motor skills, language skills, and temperament/personality in relation to fundamental epidemiologic and genetic factors. Part 2: The cross-sectional studies of school-age children and adults extend the subtype hypothesis to older individuals who stutter. Performance is measured across the same domains as in Part 1. Part 3: The longitudinal/cross-sectional comparison integrates patterns in the longitudinal study with those in school-age children and adults. The combination of longitudinal with cross-sectional data thus allows for the first integration of multidimensional traits associated with stuttering across the age span from preschool to adulthood. The longitudinal data and much of the cross-sectional data have been collected during the first cycle of the grant and are ready for analyses aimed at subtypes identification. Because of the ambitious size of this multi- center project, and particularly in view of its longitudinal nature of the study which only yields critical data on persistency vs. recovery at its end, a good portion of the relevant data became available only recently, and can be now reduced and analyzed to allow the subtyping hypotheses to be definitively tested. This renewal proposal of the grant focuses on, first, profiling multi-domain attributes to identify subtypes of stuttering in preschool children;and second, extending the subtype hypotheses to older children and adults who stutter, by comparing profiles in the same domains in these populations.

Public Health Relevance

Delineation of stuttering subtypes has ecological relevance in that it will advance knowledge and treatment of stuttering by a) reducing noise in recovery predictions;b) identifying individuals who are more resistant to treatment;c) allowing earlier intervention with children prone to persistency;and d) prompting suitable treatment development for the respective subtypes. Accordingly, the societal value of subtype delineation is the promise of reducing the communicative and economic impacts suffered by adults and children who stutter.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC005210-08
Application #
8460438
Study Section
Motor Function, Speech and Rehabilitation Study Section (MFSR)
Program Officer
Shekim, Lana O
Project Start
2002-04-01
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
8
Fiscal Year
2013
Total Cost
$329,598
Indirect Cost
$115,848
Name
University of Illinois Urbana-Champaign
Department
Other Health Professions
Type
Other Domestic Higher Education
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Jo Kraft, Shelly; Ambrose, Nicoline; Chon, HeeCheong (2014) Temperament and environmental contributions to stuttering severity in children: the role of effortful control. Semin Speech Lang 35:80-94
Yairi, Ehud; Ambrose, Nicoline (2013) Epidemiology of stuttering: 21st century advances. J Fluency Disord 38:66-87
Mahurin-Smith, Jamie; Ambrose, Nicoline G (2013) Breastfeeding may protect against persistent stuttering. J Commun Disord 46:351-60
Yairi, Ehud (2013) Defining stuttering for research purposes. J Fluency Disord 38:294-8
Choo, Ai Leen; Chang, Soo-Eun; Zengin-Bolatkale, Hatun et al. (2012) Corpus callosum morphology in children who stutter. J Commun Disord 45:279-89
Ortega, Aishah Y; Ambrose, Nicoline G (2011) Developing physiologic stress profiles for school-age children who stutter. J Fluency Disord 36:268-73
Tumanova, Victoria; Zebrowski, Patricia M; Throneburg, Rebecca N et al. (2011) Articulation rate and its relationship to disfluency type, duration, and temperament in preschool children who stutter. J Commun Disord 44:116-29
Loucks, Torrey; Kraft, Shelly Jo; Choo, Ai Leen et al. (2011) Functional brain activation differences in stuttering identified with a rapid fMRI sequence. J Fluency Disord 36:302-7
Sawyer, Jean; Yairi, Ehud (2010) Characteristics of disfluency clusters over time in preschool children who stutter. J Speech Lang Hear Res 53:1191-205
Buhr, Anthony; Zebrowski, Patricia (2009) Sentence position and syntactic complexity of stuttering in early childhood: a longitudinal study. J Fluency Disord 34:155-72

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