In the previous funding period we identified areas of the brain essential for distinct cognitive processes underlying lexical tasks, by identifying areas of tissue dysfunction associated with specific lexical deficits immediately after left hemisphere ischemic stroke in 317 patients. We used MRI scans, including diffusion weighted imaging and perfusion weighted imaging, to identify dysfunctional tissue and language tests to identify deficits in lexical processing within 24 hours of stroke onset. We also determined which deficits recovered in association with tissue recovery in specific regions by Day 3-5. We found new evidence that lexical tasks such as naming, reading, and spelling depend on overlapping networks of brain regions, but that distinct cognitive processes underlying these tasks depend differentially on one or more of the neural regions in this network. In this competitive continuation we propose to use this methodology to investigate the neural regions critical for a number of language and cognitive processes that all have been hypothesized to rely on Broca's area, or have been reported to be impaired in patients with Broca's aphasia, or both. We will test specific hypotheses about cognitive processes that depend on Broca's area (based on functional imaging and chronic lesion studies), and hypotheses about cognitive/linguistic deficits underlying Broca's aphasia (generated from psycholinguistic and neuropsychological studies).
We aim to determine what cognitive functions underlying language are specifically associated with acute damage/dysfunction of Broca's area and/or chronic damage to Broca's area. In addition, we aim to determine whether or not impairments of these functions are associated with the clinical diagnosis of Broca's aphasia, or components of this clinical syndrome, in the acute or chronic stage. This research is expected to clarify the role of Broca's area in language and cognitive processing, and to clarify the relationship between deficits in cognitive functions attributed to Broca's area and the language characteristics of Broca's aphasia (e.g. agrammatic speech, apraxia of speech, and asyntactic comprehension). We expect the results to contribute to the understanding of the neural and cognitive mechanisms underlying sentence comprehension and production. The results will also have clinical impact by aiding in functional prognosis in acute stroke and in identifying appropriate candidates for intervention to restore blood flow in patients with language deficits due to acute stroke.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
Project #
Application #
Study Section
Special Emphasis Panel (ZRG1-BBBP-C (02))
Program Officer
Cooper, Judith
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Johns Hopkins University
Schools of Medicine
United States
Zip Code
Purcell, Jeremy; Sebastian, Rajani; Leigh, Richard et al. (2017) Recovery of orthographic processing after stroke: A longitudinal fMRI study. Cortex 92:103-118
Shahid, Hinna; Sebastian, Rajani; Schnur, Tatiana T et al. (2017) Important considerations in lesion-symptom mapping: Illustrations from studies of word comprehension. Hum Brain Mapp 38:2990-3000
Hillis, Argye E; Rorden, Christopher; Fridriksson, Julius (2017) Brain regions essential for word comprehension: Drawing inferences from patients. Ann Neurol 81:759-768
Sebastian, Rajani; Tsapkini, Kyrana; Tippett, Donna C (2016) Transcranial direct current stimulation in post stroke aphasia and primary progressive aphasia: Current knowledge and future clinical applications. NeuroRehabilitation 39:141-52
Agis, Daniel; Goggins, Maria B; Oishi, Kumiko et al. (2016) Picturing the Size and Site of Stroke With an Expanded National Institutes of Health Stroke Scale. Stroke 47:1459-65
Rapp, Brenda; Purcell, Jeremy; Hillis, Argye E et al. (2016) Neural bases of orthographic long-term memory and working memory in dysgraphia. Brain 139:588-604
Kodumuri, Nishanth; Sebastian, Rajani; Davis, Cameron et al. (2016) The association of insular stroke with lesion volume. Neuroimage Clin 11:41-5
Sebastian, Rajani; Saxena, Sadhvi; Tsapkini, Kyrana et al. (2016) Cerebellar tDCS: A Novel Approach to Augment Language Treatment Post-stroke. Front Hum Neurosci 10:695
Tippett, Donna C (2015) Update in Aphasia Research. Curr Neurol Neurosci Rep 15:49
Bonekamp, David; Barker, Peter B; Leigh, Richard et al. (2015) Susceptibility-based analysis of dynamic gadolinium bolus perfusion MRI. Magn Reson Med 73:544-54

Showing the most recent 10 out of 87 publications