The broad objective of the proposed studies is to apply design, dynamic testing, and material testing methods from Mechanical Engineering to better understand the impact of existing and new vocal fold implants and prostheses for vocal fold medialization, partial or total lamina propria reconstruction on the mechanical properties and dynamic response of native laryngeal tissue and, ultimately, voice quality. It is postulated that the systematic application of the proposed methods will eventually help the creation of implants and prostheses with mechanical behavior representative of native tissue that are robust and durable. Much work has been done on the use of vocal fold implants and prostheses for the surgical repair of vocal pathologies involving the lamina propria, such as scarring, sulcus vocalis, and atrophy, which remain challenging clinical problems in laryngology and phonosurgery. Biomaterials used have included specific types of fat, collagen, hyaluronic acid, fascia, and a variety of synthetic materials such as silicone, Gore-Tex, or hydroxyapatite. Previous work has been done without a detailed knowledge of the mechanical properties and response of the synthetic or biological materials used. This may have resulted in sub-optimal oscillatory function, and reduced voice quality. The present study aims at developing and evaluating synthetic models, implants, and prostheses with a set of mechanical properties that closely match measured data for human vocal fold tissue. Synthetic models of the larynx will be perfected and used for fundamental studies, as well as test beds for new implants. Digital image correlation methods will be developed in order to obtain dynamic, full field strain data and stress estimates that will help quantify the influence of prosthesis and implants on mechanical response. The dependence of the vocal folds resonance frequencies on tension, air flow rate, and implant design will be quantified. The influence of selected matrix proteins on the viscoelastic properties of the lamina propria will be measured in order to better under the consequences of the biological response of the tissue to foreign inclusions. The issues of bonding between implants and native tissue will be examined using atomic force microscopy.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC005788-09
Application #
8310760
Study Section
Motor Function, Speech and Rehabilitation Study Section (MFSR)
Program Officer
Shekim, Lana O
Project Start
2002-11-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2014-08-31
Support Year
9
Fiscal Year
2012
Total Cost
$339,920
Indirect Cost
$9,139
Name
Mcgill University
Department
Type
DUNS #
205667090
City
Montreal
State
PQ
Country
Canada
Zip Code
H3 0-G4
Seekhao, Nuttiiya; Shung, Caroline; JaJa, Joseph et al. (2016) Real-Time Agent-Based Modeling Simulation with in-situ Visualization of Complex Biological Systems: A Case Study on Vocal Fold Inflammation and Healing. IEEE Int Symp Parallel Distrib Process Workshops Phd Forum 2016:463-472
Latifi, Neda; Heris, Hossein K; Thomson, Scott L et al. (2016) A Flow Perfusion Bioreactor System for Vocal Fold Tissue Engineering Applications. Tissue Eng Part C Methods 22:823-38
Heris, Hossein K; Daoud, Jamal; Sheibani, Sara et al. (2016) Investigation of the Viability, Adhesion, and Migration of Human Fibroblasts in a Hyaluronic Acid/Gelatin Microgel-Reinforced Composite Hydrogel for Vocal Fold Tissue Regeneration. Adv Healthc Mater 5:255-65
Kazemirad, Siavash; Heris, Hossein K; Mongeau, Luc (2016) Viscoelasticity of hyaluronic acid-gelatin hydrogels for vocal fold tissue engineering. J Biomed Mater Res B Appl Biomater 104:283-90
Miri, Amir K; Chen, Lei Xi; Mongrain, Rosaire et al. (2016) Fracture Toughness of Vocal Fold Tissue: A Preliminary Study. J Voice 30:251-4
Miri, Amir K; Li, Nicole Y K; Avazmohammadi, Reza et al. (2015) Study of extracellular matrix in vocal fold biomechanics using a two-phase model. Biomech Model Mechanobiol 14:49-57
Asgari, Meisam (2015) A molecular model for the free energy, bending elasticity, and persistence length of wormlike micelles. Eur Phys J E Soft Matter 38:98
Asgari, Meisam; Biria, Aisa (2015) Free energy of the edge of an open lipid bilayer based on the interactions of its constituent molecules. Int J Non Linear Mech 76:135-143
Kosinski, Aaron M; Pothen, Jewel M; Panitch, Alyssa et al. (2015) Dexamethasone Controlled Release on TGF-β1 Treated Vocal Fold Fibroblasts. Ann Otol Rhinol Laryngol 124:572-8
Heris, Hossein K; Miri, Amir K; Ghattamaneni, Nageswara R et al. (2015) Microstructural and mechanical characterization of scarred vocal folds. J Biomech 48:708-11

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