The postnatal growth of the oral and pharyngeal structures and their respective cavities - that define the vocal tract (VT) - entails changes in size, shape, and relative proportions. While prenatal and postnatal growth comprise a developmental continuum, current theory strongly associates the postnatal functions of the VT structures to guide its growth, particularly during infancy and early childhood. Acoustic theory affirms a relationship between the anatomy of the developing VT and the spectrum of speech sounds observed during development. However, although the available anatomic information remains inadequate to explain this relationship in detail, our VT Development Lab has made steady progress since 2000 towards its mission to quantitatively characterize sex-specific anatomic changes of the supralaryngeal speech system during development by: i) Establishing a unique imaging database consisting of 1116 MRI and CT studies across the lifespan that is representative of both sexes. ii) Compiling a large set of measurements that capture the concurrent growth of the head, face and VT structures throughout the lifespan;and creating composite 3D models where the spatial relation between select VT structures is maintained and from which measurements on relational growth will be secured. iii) Characterizing systematically the individual and relational growth of VT structures (ex. Vorperian et al. 1999, 2005), and synthesizing findings on the acoustic output of the developing VT, specifically the development of vowel acoustic space (Vorperian &Kent, 2007). This proposed project combines imaging, acoustic analysis of speech, acoustic reflection or acoustic pharyngometry data, and VT modeling in an investigation on the development of the supra-laryngeal speech apparatus throughout the lifespan. The goals of this proposed research are to: (1) Expand the imaging and the measurements databases to include atypically developing cases, supplement measurements that are guided by embryologic origin of structures, and measurements from 3D models that capture additional information on the relational growth of VT structures. Also, to secure speech recordings and acoustic pharyngometry data mostly from individuals who will be imaged. (2) Assess perspectives on anatomic- acoustic relationships and structure/function interaction by statistically characterizing sex specific growth models and growth type of the VT structures in typically and atypically developing individuals;and assess their relative and relational growth while taking into account the structures'tissue type (bony, soft, cartilage and cavity), embryologic origin, plane of growth, and/or functional use. (3) Use complementary imaging and acoustic reflection data to configure developmental VT models and correlate model computed formant values with age specific acoustic data to make inferences regarding VT acoustic characteristics to developmental changes of specific anatomic structures. The findings will provide a coherent and much needed picture on the development of VT structures from embryo to geriatrics. Such information is foundational for both theoretical constructs and clinical application in multiple disciplines that deal with craniofacial structures and functions.

Public Health Relevance

/Relevance of this research to public health Imaging and acoustic methods are used to provide detailed information on the structural development of the oral and pharyngeal structures in both typically and atypically developing individuals. Anatomic data from typically developing individuals of both sexes will establish normative references for the growth of the oral and pharyngeal structures, along with their respective cavities and the vocal tract itself. This information is essential and valuable to a number of clinical disciplines - particularly those concerned with craniofacial anomalies - that are concerned with behaviors such as feeding, swallowing, speech production, and respiration. In addition, this information can be used to determine the efficacy of intervention strategies that effect developmental changes in anatomy, physiology, or acoustic output.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC006282-10
Application #
8499279
Study Section
Motor Function, Speech and Rehabilitation Study Section (MFSR)
Program Officer
Shekim, Lana O
Project Start
2003-08-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$505,217
Indirect Cost
$162,935
Name
University of Wisconsin Madison
Department
Pediatrics
Type
Other Domestic Higher Education
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Kelly, Michael P; Vorperian, Houri K; Wang, Yuan et al. (2017) Characterizing mandibular growth using three-dimensional imaging techniques and anatomic landmarks. Arch Oral Biol 77:27-38
Chuang, Ying Ji; Doherty, Benjamin M; Adluru, Nagesh et al. (2017) A Novel Registration-Based Semiautomatic Mandible Segmentation Pipeline Using Computed Tomography Images to Study Mandibular Development. J Comput Assist Tomogr :
Wild, Alyssa; Vorperian, Houri K; Kent, Ray D et al. (2017) Single-Word Speech Intelligibility in Children and Adults With Down Syndrome. Am J Speech Lang Pathol :1-15
Eichhorn, Julie Traub; Kent, Raymond D; Austin, Diane et al. (2017) Effects of Aging on Vocal Fundamental Frequency and Vowel Formants in Men and Women. J Voice :
Wang, Yuan; Chung, Moo K; Vorperian, Houri K (2016) Composite growth model applied to human oral and pharyngeal structures and identifying the contribution of growth types. Stat Methods Med Res 25:1975-1990
Fisher, Ellie; Austin, Diane; Werner, Helen M et al. (2016) Hyoid bone fusion and bone density across the lifespan: prediction of age and sex. Forensic Sci Med Pathol 12:146-57
Derdemezis, Ekaterini; Vorperian, Houri K; Kent, Ray D et al. (2016) Optimizing Vowel Formant Measurements in Four Acoustic Analysis Systems for Diverse Speaker Groups. Am J Speech Lang Pathol 25:335-54
Chung, Moo K; Qiu, Anqi; Seo, Seongho et al. (2015) Unified heat kernel regression for diffusion, kernel smoothing and wavelets on manifolds and its application to mandible growth modeling in CT images. Med Image Anal 22:63-76
Kent, Ray D (2015) Nonspeech Oral Movements and Oral Motor Disorders: A Narrative Review. Am J Speech Lang Pathol 24:763-89
Cotter, Meghan M; Whyms, Brian J; Kelly, Michael P et al. (2015) Hyoid Bone Development: An Assessment Of Optimal CT Scanner Parameters and Three-Dimensional Volume Rendering Techniques. Anat Rec (Hoboken) 298:1408-15

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