Otitis media (OM) is one of the most prevalent diseases in children and cost the US healthcare system an estimated $5 billion dollars annually. Although the primary etiology responsible for the persistence of OM conditions is a dysfunctional Eustachian tube (ET), standard treatment therapies for OM do not address the underlying biomechanical and structural abnormalities responsible for ET dysfunction. Recently, several clinical therapies which target specific mechanical and/or physical properties have been suggested to improve ET function. However, the relative effectiveness of these therapies in patient populations with different structural pathologies is not known. Therefore, the goal of this research program is to develop an in- depth understanding of how various biomechanical and biophysical properties influence ET function in different OM prone patient populations. Due to the large number of physical properties, and the complex interactions among these properties, we will elucidate the mechanisms responsible for ET dysfunction using a sophisticated multi-scale computational approach. First, established computational modeling techniques will be used to investigate how the pathological anatomy of ET tissues influences opening phenomena in various OM prone populations. Second, fluid-structure interactions and multi-scale phenomena will be incorporated into the tissue deformation models in order to investigate how various clinically relevant properties (i.e. surface tension and mucosal adhesion forces) influence ET opening. Several sensitivity analyses will be performed to identify which biomechanical or biophysical properties have the greatest impact on ET function in different patient populations. In addition, the computational models will be used to estimate changes in ET function during various pathological conditions. As a result, this research will identify the biomechanical and biophysical mechanisms responsible for ET dysfunction. This information is vital to the development of novel treatment therapies that seek to restore normal ET function in patients with OM. ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC007230-02
Application #
7222701
Study Section
Auditory System Study Section (AUD)
Program Officer
Watson, Bracie
Project Start
2006-07-01
Project End
2011-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
2
Fiscal Year
2007
Total Cost
$136,558
Indirect Cost
Name
Lehigh University
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
808264444
City
Bethlehem
State
PA
Country
United States
Zip Code
18015
Zielinski, Rachel; Mihai, Cosmin; Kniss, Douglas et al. (2013) Finite element analysis of traction force microscopy: influence of cell mechanics, adhesion, and morphology. J Biomech Eng 135:71009
Sheer, F J; Swarts, J D; Ghadiali, S N (2012) Three-dimensional finite element analysis of Eustachian tube function under normal and pathological conditions. Med Eng Phys 34:605-16
Ghadiali, Samir; Huang, Y (2011) Role of airway recruitment and derecruitment in lung injury. Crit Rev Biomed Eng 39:297-317
Ghadiali, Samir N; Bell, E David; Swarts, J Douglas (2010) Timing of tensor and levator veli palatini force application determines eustachian tube resistance patterns during the forced-response test. Auris Nasus Larynx 37:720-9
Sheer, F J; Swarts, J D; Ghadiali, S N (2010) Finite element analysis of eustachian tube function in cleft palate infants based on histological reconstructions. Cleft Palate Craniofac J 47:600-10
Huang, Yan; Haas, Caroline; Ghadiali, Samir N (2010) Influence of Transmural Pressure and Cytoskeletal Structure on NF-?B Activation in Respiratory Epithelial Cells. Cell Mol Bioeng 3:415-427
Ghadiali, Samir N; Gaver, Donald P (2008) Biomechanics of liquid-epithelium interactions in pulmonary airways. Respir Physiol Neurobiol 163:232-43