Voice disorders result from the disruption of normal vocal fold vibration during phonation. The current gold standard for assessing voice disorders is visual endoscopic examination via videostroboscopy. However, technical limitations that are inherent to stroboscopic imaging (i.e., generating a composite image that is assembled across many cycles of vibration) restrict the clinical and research utility of videostroboscopy. High-speed imaging has the potential to capture the true cycle-to-cycle vibratory behavior of the vocal folds, which should theoretically overcome the limitations of videostroboscopy, and provide the potential for more accurate objective quantification of vocal fold vibratory behavior. Vocal fold high-speed imaging has a long research history, and the relatively recent commercial introduction of laryngeal high-speed videoendoscopy (HSV) has served to increase its availability for clinical and research use. However, these HSV systems have not gained widespread adoption because of remaining methodological limitations (eg., compromised image quality;lack of tools to extract the rich visual content, difficulty managing and analyzing the massive amounts of data generated by HSV, etc.), and an associated lack of information regarding the validity, practicality, and clinical relevance of HSV. The primary purpose of this project is to develop improved HSV-based methods for the visualization and automatic measurement of vocal fold vibratory characteristics that will facilitate the clinical and research use of this technology, and to begin establishing the clinical validity, practicality, and relevance of HSV in the functional evaluation of vocal fold pathology. The overriding hypothesis is that HSV can be developed into a robust tool that will provide new insights into the biomechanics of laryngeal sound production (particularly when combined with other simultaneous measures), as well as enable more accurate functional assessment of the pathophysiology of voice disorders leading to important refinements in the diagnosis of vocal fold pathology. The primary purpose requires a series of experiments to improve HSV technology, develop analysis techniques, establish a clinical protocol, collect data, and evaluate the reliability, validity, and relevance of HSV in the clinical assessment of voice disorders. This project proposes a comprehensive approach addressing all of the above tasks, through the collaboration of leading scientists and clinicians.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
7R01DC007640-05
Application #
8020048
Study Section
Special Emphasis Panel (ZRG1-BBBP-E (03))
Program Officer
Shekim, Lana O
Project Start
2007-02-01
Project End
2014-01-31
Budget Start
2011-02-01
Budget End
2014-01-31
Support Year
5
Fiscal Year
2011
Total Cost
$516,244
Indirect Cost
Name
Cincinnati Children's Hospital Medical Center
Department
Type
DUNS #
071284913
City
Cincinnati
State
OH
Country
United States
Zip Code
45229
Deliyski, Dimitar D; Hillman, Robert E; Mehta, Daryush D (2015) Laryngeal High-Speed Videoendoscopy: Rationale and Recommendation for Accurate and Consistent Terminology. J Speech Lang Hear Res 58:1488-92
Luegmair, Georg; Mehta, Daryush D; Kobler, James B et al. (2015) Three-Dimensional Optical Reconstruction of Vocal Fold Kinematics Using High-Speed Video With a Laser Projection System. IEEE Trans Med Imaging 34:2572-82
Orlikoff, Robert F; Golla, Maria E; Deliyski, Dimitar D (2012) Analysis of longitudinal phase differences in vocal-fold vibration using synchronous high-speed videoendoscopy and electroglottography. J Voice 26:816.e13-20
Mehta, Daryush D; Hillman, Robert E (2012) Current role of stroboscopy in laryngeal imaging. Curr Opin Otolaryngol Head Neck Surg 20:429-36
Bonilha, Heather Shaw; White, Lisa; Kuckhahn, Kelsey et al. (2012) Vocal fold mucus aggregation in persons with voice disorders. J Commun Disord 45:304-11
Mehta, Daryush D; Zeitels, Steven M; Burns, James A et al. (2012) High-speed videoendoscopic analysis of relationships between cepstral-based acoustic measures and voice production mechanisms in patients undergoing phonomicrosurgery. Ann Otol Rhinol Laryngol 121:341-7
Bonilha, Heather Shaw; Deliyski, Dimitar D; Whiteside, Joanna Piasecki et al. (2012) Vocal fold phase asymmetries in patients with voice disorders: a study across visualization techniques. Am J Speech Lang Pathol 21:3-15
Döllinger, Michael; Kobler, James; Berry, David A et al. (2011) Experiments on Analysing Voice Production: Excised (Human, Animal) and In Vivo (Animal) Approaches. Curr Bioinform 6:286-304
Mehta, Daryush D; Deliyski, Dimitar D; Quatieri, Thomas F et al. (2011) Automated measurement of vocal fold vibratory asymmetry from high-speed videoendoscopy recordings. J Speech Lang Hear Res 54:47-54
Zañartu, Matías; Mehta, Daryush D; Ho, Julio C et al. (2011) Observation and analysis of in vivo vocal fold tissue instabilities produced by nonlinear source-filter coupling: a case study. J Acoust Soc Am 129:326-39

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