The proposed studies will investigate interactions between cortical and subcortical brain regions during speech production by measuring regional cerebral blood flow (rCBF) with positron emission tomography (PET) in Parkinson's disease (PD) subjects, PD subjects with deep brain stimulation (DBS) of the subthalamic nuclei (STN), and normal subjects. The use of DBS of the STN to treat PD provides a reversible means of modifying the activity of sub-cortical areas including the striatum, globus pallidus, and thalamus. While effective in reducing non-speech motor symptoms, this form of therapy often has no effect or even a negative effect on speech, raising questions about the relationship between speech and non- speech motor control in PD, and more generally, about the nature of cortical-subcortical interactions during speech. We have previously observed a reliable inverse relationship between rCBF in the caudate and inferior frontal area as a function of speech rate in normal and ataxic speakers. The proposed studies will further explore this relationship and the ways in which it is altered by PD and by DBS of the STN by mapping brain activity during a series of controlled speech production tasks. The concurrent measurement and subsequent analysis of rCBF and speech production has already produced significant insight into the functional significance of imaging data. The proposed studies should yield significant ^progress in understanding cortical-subcortical interactions during speech in normal speakers andin speakers whose fluency has been affected by PD and DBS. This project will also characterizehow such interactions are affected by task demands, and how PD, DBS, and task demands interact. The goal is to better understand cbrtical-subcprtical interactions in normal and dysfluent speech, and the role of-such interactions in specific aspects of speech production. The ability to speak clearly involves a complex brain system that is not fully understood. Parkinson's Disease interferes with this ability. This researchwill study the effects of Parkinson's Disease and one formof treatment on brain activity during speech to better understand this system. This may lead to new therapies for speech disorders in neurological diseases.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Research Project (R01)
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Motor Function, Speech and Rehabilitation Study Section (MFSR)
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Shekim, Lana O
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Nathan Kline Institute for Psychiatric Research
United States
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Sidtis, John J; Alken, Amy G; Tagliati, Michele et al. (2016) Subthalamic Stimulation Reduces Vowel Space at the Initiation of Sustained Production: Implications for Articulatory Motor Control in Parkinson's Disease. J Parkinsons Dis 6:361-70
Van Lancker Sidtis, Diana; Choi, JiHee; Alken, Amy et al. (2015) Formulaic Language in Parkinson's Disease and Alzheimer's Disease: Complementary Effects of Subcortical and Cortical Dysfunction. J Speech Lang Hear Res 58:1493-507
Sidtis, John J (2015) Functional connectivity associated with acoustic stability during vowel production: implications for vocal-motor control. Brain Connect 5:115-25
Van Lancker Sidtis, Diana; Cameron, Krista; Bridges, Kelly et al. (2015) The formulaic schema in the minds of two generations of native speakers. Ampersand (Oxford) 2:39-48
Elahi, Sahar; Bachman, Alvin H; Lee, Sang Han et al. (2015) Corpus callosum atrophy rate in mild cognitive impairment and prodromal Alzheimer's disease. J Alzheimers Dis 45:921-31
Ardekani, Babak A; Bachman, Alvin H; Figarsky, Khadija et al. (2014) Corpus callosum shape changes in early Alzheimer's disease: an MRI study using the OASIS brain database. Brain Struct Funct 219:343-52
Bachman, Alvin H; Lee, Sang Han; Sidtis, John J et al. (2014) Corpus callosum shape and size changes in early Alzheimer's disease: a longitudinal MRI study using the OASIS brain database. J Alzheimers Dis 39:71-8
Ahn, Ji Sook; Van Lancker Sidtis, Diana; Sidtis, John J (2014) Effects of Deep Brain Stimulation on Pausing During Spontaneous Speech in Parkinson's Disease. J Med Speech Lang Pathol 21:179-186
Ardekani, Babak A; Figarsky, Khadija; Sidtis, John J (2013) Sexual dimorphism in the human corpus callosum: an MRI study using the OASIS brain database. Cereb Cortex 23:2514-20
Bridges, Kelly A; Van Lancker Sidtis, Diana; Sidtis, John J (2013) The role of subcortical structures in recited speech: Studies in Parkinson's disease. J Neurolinguistics 26:594-601

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