The proposed project will continue and extend our present studies on cortical-subcortical interactions during speech using the effects of PD and DBS to probe the neurological basis of motor speech control, and the effects of PD and DBS on speech. Continuing our functional imaging with PET, we will add structural imaging, diffusion tensor imaging, and tractography using MRI. We will continue probing speech with a range of tasks incorporating reading, recitation, repetition, and spontaneous speech. We will evaluate intelligibility and perceptual ratings, using these results to inform acoustic analyses. We are adding expertise in statistical modeling and the application of MRI to the study of voice pathology. Our goal is to answer basic clinical and speech science questions. Several fundamental questions need to be addressed in this field. Clinically, we need a better estimate of how often DBS results in greater speech impairment, and when it occurs, how it can be characterized. We need to understand the extent to which DBS-related speech impairments result from changes in brain networks for speech, global brain effects, and/or stimulation of motor tracts adjacent to the subthalamic nucleus. From the speech science perspective, we need to characterize cortical-subcortical interactions for a range of speech tasks to better understand the role of the basal ganglia, cortical, and cerebellar regions in speech. We are approaching the goals of this project with a combination of well-controlled experimental studies, studies of special cases that may be especially informative, and an innovative approach to clinical survey studies. Our finding that DBS enhances some components of speech while retarding others provides an important step in understanding an inconsistent literature. Further, analysis of our PET data suggests that DBS changes the basic relationship between speech and cortical-subcortical interactions. Our major working hypotheses are that: cortical lateral asymmetry is associated with fluency;subcortical regions are strongly associated with phonation, particularly the first two formants, and these are shifted during DBS;when DBS strengthens phonation, an additional burden is placed on articulatory control;both brain and speech effects are task dependent, with the greatest difficulty observed during conversation. Our work also suggests that global blood flow is related to pausing during speech, with DBS on and off, and in PD subjects without DBS. This may reflect the integrity of the central nervous system in PD, and will be further examined with diffusion tensor imaging. In addition to the detailed imaging studies, we will conduct a broader, clinic-based study of conversational and repeated speech before and after DBS surgery. Taken together, these studies should provide a better understanding of the range and severity of speech changes following DBS, and the brain changes associated with these changes.

Public Health Relevance

Parkinson's disease (PD) is a progressive movement disorder that impairs the ability to speak clearly. Deep brain stimulation (DBS) improves many of the motor symptoms of PD, but does not help and sometimes harms the ability to speak. This project seeks to understand the effects of PD and DBS on speech with the long-term goals of (1) modifying DBS to preserve or improve speech in PD and (2) improving our understanding of cortical-subcortical interactions during speech.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC007658-08
Application #
8642618
Study Section
Special Emphasis Panel (ZRG1-BBBP-E (04))
Program Officer
Shekim, Lana O
Project Start
2005-07-01
Project End
2017-03-31
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
8
Fiscal Year
2014
Total Cost
$440,768
Indirect Cost
$128,866
Name
Nathan Kline Institute for Psychiatric Research
Department
Type
DUNS #
167204762
City
Orangeburg
State
NY
Country
United States
Zip Code
10962
Ardekani, Babak A; Bachman, Alvin H; Figarsky, Khadija et al. (2014) Corpus callosum shape changes in early Alzheimer's disease: an MRI study using the OASIS brain database. Brain Struct Funct 219:343-52
Bachman, Alvin H; Lee, Sang Han; Sidtis, John J et al. (2014) Corpus callosum shape and size changes in early Alzheimer's disease: a longitudinal MRI study using the OASIS brain database. J Alzheimers Dis 39:71-8
Bridges, Kelly A; Van Lancker Sidtis, Diana; Sidtis, John J (2013) The role of subcortical structures in recited speech: Studies in Parkinson's disease. J Neurolinguistics 26:594-601
Bridges, Kelly Ann; Van Lancker Sidtis, Diana (2013) Formulaic Language in Alzheimer's Disease. Aphasiology 27:
Sidtis, Diana; Kreiman, Jody (2012) In the beginning was the familiar voice: personally familiar voices in the evolutionary and contemporary biology of communication. Integr Psychol Behav Sci 46:146-59
Morris, Tiffany R; Cho, Catherine; Dilda, Valentina et al. (2012) A comparison of clinical and objective measures of freezing of gait in Parkinson's disease. Parkinsonism Relat Disord 18:572-7
Sidtis, John J; Tagliati, Michele; Alterman, Ron et al. (2012) Therapeutic high-frequency stimulation of the subthalamic nucleus in Parkinson's disease produces global increases in cerebral blood flow. J Cereb Blood Flow Metab 32:41-9
Sidtis, John J (2012) Performance-based connectivity analysis: a path to convergence with clinical studies. Neuroimage 59:2316-21
Sidtis, John J; Ahn, Ji Sook; Gomez, Christopher et al. (2011) Speech characteristics associated with three genotypes of ataxia. J Commun Disord 44:478-92
Sidtis, John J; Strother, Stephen C; Groshong, Ansam et al. (2010) Longitudinal cerebral blood flow changes during speech in hereditary ataxia. Brain Lang 114:43-51

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