Auditory research into the neural basis of communication sound processing has generally been conducted without accounting for the social contexts in which communication naturally occurs. Hence, how the auditory system is able detect, discriminate and categorize communication calls despite natural speaker variability is poorly understood, as are the mechanisms by which social interactions affect this processing. Our long-term goal is to uncover the circuit, cellular and molecular mechanisms underlying the auditory system's encoding of socially-acquired vocalizations, so that causes underlying deficits in natural communication processing can be inferred. We pursue this in a mouse model of ultrasound communication wherein two categories of calls (those emitted by mouse pups and by adult males) carry different meanings and can have different levels of behav- ioral relevance to a female. The objective here is to uncover how the representation of these call categories is transformed by hierarchical processing from a primary to a higher-order auditory cortical field, and how differ- ent natural social experiences with the calls produce coding changes. Our central hypothesis is that the trans- formation refines call coding to facilitate communication tasks, and that social experience and neurochemical systems modify this neural transformation as behavioral relevance is acquired. The rationale for this research is that once we know the manner by which neural plasticity in auditory cortex shapes the coding of behaviorally relevant calls, we will be able to exploit the transgenic advantages of the mouse model to dissect the detailed mechanisms enabling these changes. Using extracellular electrophysiology in awake mice, we will test our hy- pothesis with three specific aims. First, we will determine how the neural transformation normally functions to refine the encoding of behaviorally relevant calls by recording from animals that recognize the significance of pup calls (mothers). Second, we will determine how social experience with pups modifies this neural transfor- mation by recording from virgin females that help care for pups (co-carers). Third, we will determine how a key social neurochemical implicated in pup call recognition, estrogen, works with pup care experience to modify the neural transformation by recording from hormonally manipulated co-carers. This proposal's significance lies in its unique ability to bridge the scientific gap between sensory and social/behavioral neuroscience in an animal model in which we can pursue future studies of a high level auditory function (communication) from a system down to a molecular level.
This research will enable us to discover mechanisms underlying the natural functioning of the processing stream between a primary and higher-order auditory cortical field in the context of species-specific communica- tion. By elucidating the normal operation of this system, our results will be important in implicating aspects of communication coding and plasticity that may fail in auditory processing disorders, social disorders with audi- tory dysfunctions, hearing loss and temporal lobe strokes.
|Miranda, Jason A; Shepard, Kathryn N; McClintock, Shannon K et al. (2014) Adult plasticity in the subcortical auditory pathway of the maternal mouse. PLoS One 9:e101630|
|Banerjee, Sunayana B; Liu, Robert C (2013) Storing maternal memories: hypothesizing an interaction of experience and estrogen on sensory cortical plasticity to learn infant cues. Front Neuroendocrinol 34:300-14|
|Lin, F G; Galindo-Leon, E E; Ivanova, T N et al. (2013) A role for maternal physiological state in preserving auditory cortical plasticity for salient infant calls. Neuroscience 247:102-16|
|Bennur, Sharath; Tsunada, Joji; Cohen, Yale E et al. (2013) Understanding the neurophysiological basis of auditory abilities for social communication: a perspective on the value of ethological paradigms. Hear Res 305:3-9|
|Shepard, K N; Liu, R C (2011) Experience restores innate female preference for male ultrasonic vocalizations. Genes Brain Behav 10:28-34|
|Ivanova, T N; Matthews, A; Gross, C et al. (2011) Arc/Arg3.1 mRNA expression reveals a subcellular trace of prior sound exposure in adult primary auditory cortex. Neuroscience 181:117-26|
|Galindo-Leon, Edgar E; Liu, Robert C (2010) Predicting stimulus-locked single unit spiking from cortical local field potentials. J Comput Neurosci 29:581-97|
|Miranda, Jason A; Liu, Robert C (2009) Dissecting natural sensory plasticity: hormones and experience in a maternal context. Hear Res 252:21-8|
|Galindo-Leon, Edgar E; Lin, Frank G; Liu, Robert C (2009) Inhibitory plasticity in a lateral band improves cortical detection of natural vocalizations. Neuron 62:705-16|
|Liu, Robert C; Schreiner, Christoph E (2007) Auditory cortical detection and discrimination correlates with communicative significance. PLoS Biol 5:e173|