The functional anatomy of the planum temporale (PT) has been of great theoretical interest for decades, and a focus of recent clinical studies of a number of disorders ranging from autism to schizophrenia. Although the (left) PT was initially thought to subserve language functions, recent basic research has shown that it is multifunctional, being implicated in such diverse processing domains as speech perception and production, tonal processing, auditory-motor integration, spatial hearing, and multi-sensory integration. Given the potential importance of the PT in both theoretical models of cortical function for a range of abilities as well as its widespread clinical implications, a more thorough understanding of the functional organization of the PT is sorely needed. The present proposal seeks to fill this gap through a series of fMRI studies using within subject designs, and organized around four specific aims.
Aim 1 is to assess activation patterns for several functions known to activate the PT, including speech perception/production, tonal/melodic perception, sensory-motor integration, visual speech perception, and spatial hearing.
Aim 2 seeks to understand the functional basis for sensory-motor activations in the PT. Sensory-motor behaviors have been strongly associated with the PT (particular on the left) both clinically and functionally.
This aim examines whether PT sensory-motor activations are more strongly aligned with the auditory system (as is typically thought) or to the vocal tract articulator system (as we have recently hypothesized). In addition, we examine this system's role in temporal sequence processing, which we believe is connected to sensory-motor function.
Aim 3 is to identify neural networks supporting the interaction of spatial hearing and speech processing. Both speech-related and spatial hearing- related functions have been associated with PT function. We examine a possible interaction of these two functions in connection with auditory stream segmentation, in particular whether activation in the PT reflects the use of spatial cues to segment auditory information into distinct objects. Finally, Aim 4 is to map the relation between spatial-speech integration and visual-speech integration. It is well known that auditory stream segregation processes can make use not only of spatial cues, but also of visual speech cues. Interestingly, processing both of these cues involves the PT suggesting a possible connection.

Public Health Relevance

The proposed research is of importance from a public-health standpoint because in recent clinical studies the planum temporale has been implicated in a number of disorders ranging from autism to schizophrenia. This brain region appears to be involved in several critical functions from language processing to integration of auditory, visual, and motor functions. In spite of its central role in sensory/cognitive functions, very little is known about how this brain area is organized, and given its widespread clinical importance, a more thorough understanding of the functional organization of this region may lead to more effective treatment strategies for cognitive dysfunctions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Deafness and Other Communication Disorders (NIDCD)
Type
Research Project (R01)
Project #
5R01DC009659-05
Application #
8372400
Study Section
Language and Communication Study Section (LCOM)
Program Officer
Cooper, Judith
Project Start
2008-12-01
Project End
2014-11-30
Budget Start
2012-12-01
Budget End
2014-11-30
Support Year
5
Fiscal Year
2013
Total Cost
$432,343
Indirect Cost
$149,766
Name
University of California Irvine
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
046705849
City
Irvine
State
CA
Country
United States
Zip Code
92697
Hickok, Gregory (2014) The architecture of speech production and the role of the phoneme in speech processing. Lang Cogn Process 29:2-20
Matchin, William; Groulx, Kier; Hickok, Gregory (2014) Audiovisual speech integration does not rely on the motor system: evidence from articulatory suppression, the McGurk effect, and fMRI. J Cogn Neurosci 26:606-20
Hickok, Gregory (2014) Toward an Integrated Psycholinguistic, Neurolinguistic, Sensorimotor Framework for Speech Production. Lang Cogn Process 29:52-59
Hickok, Gregory (2013) Predictive coding? Yes, but from what source? Behav Brain Sci 36:358
Hickok, Gregory (2013) Do mirror neurons subserve action understanding? Neurosci Lett 540:56-8
Hickok, Gregory (2012) Computational neuroanatomy of speech production. Nat Rev Neurosci 13:135-45
Hickok, Gregory; Houde, John; Rong, Feng (2011) Sensorimotor integration in speech processing: computational basis and neural organization. Neuron 69:407-22
Buchsbaum, Bradley R; Baldo, Juliana; Okada, Kayoko et al. (2011) Conduction aphasia, sensory-motor integration, and phonological short-term memory - an aggregate analysis of lesion and fMRI data. Brain Lang 119:119-28
Hsieh, I-Hui; Petrosyan, Agavni; Goncalves, Oscar F et al. (2011) Observer weighting of interaural cues in positive and negative envelope slopes of amplitude-modulated waveforms. Hear Res 277:143-51
Hickok, Gregory (2010) The role of mirror neurons in speech and language processing. Brain Lang 112:1-2

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